p53 Correlation with Triple-negative Breast Cancer and Potential Treatments

Yucheng Bi

pp.1-8 DOI: 10.62051/q0djfh23

Abstract: Triple-negative breast cancer (TNBC) poses significant challenges in the field of oncology due to its prevalence and difficulty in treatment. TP53, which codes for a tumor-suppressing transcription factor p53, is crucial for the prevention of tumor development. When mutated, its role is reversed, as mutp53 provides new oncogenic properties and is correlated with the onset of cancers. Studies have presented a strong correlation between mutp53 and TNBC tumorigenesis by providing metastatic … Read More

Applications of the Tumor Microenvironment in Breast Cancer Treatment

Siyu Huo

pp.9-16 DOI: 10.62051/nmjz3279

Abstract: Research on the tumor microenvironment (TME) in breast cancer (BC) has witnessed substantial advancements in recent decades, with a growing emphasis on elucidating its key cellular and molecular components as well as their dual roles in either promoting or suppressing tumor progression. These investigations have laid the foundation for innovative therapeutic strategies targeting TME dynamics. Clinically, the heterogeneity of TME has already been exploited for diagnostic purposes, while an … Read More

Immune Checkpoint Inhibitors: Review, Challenge and Future Prospect

Ruitong Pan

pp.17-25 DOI: 10.62051/meg6n461

Abstract: As known, Immune checkpoint inhibitors (ICIs) are an emerging pillar of immunotherapy, which significantly reduce toxicity compared to traditional therapies. By blocking immune checkpoint-related signaling pathways, ICIs relieve T-cell suppression and activate anti-tumor immune responses. Nowadays, ICIs have achieved desirable effects in a wide range of advanced cancers, and many new blocking targets have entered clinical trials. However, the clinical application of ICIs continues to face dual … Read More

Risk Factors and Current Therapeutic Approaches for Hepatocellular Carcinoma

Jiahui Wu

pp.26-33 DOI: 10.62051/55pna938

Abstract: Hepatocellular carcinoma, known as HCC, is known to be the most common liver cancer. Currently, there is ongoing research on discovering the risk factors and treatment methods for HCC to find out new treatment methods for HCC that are more effective and have fewer side effects. In this research paper, the risk factors that can cause HCC and their mechanism, as well as current treatment methods for HCC, are listed. The risk factors include biological factors such as HBV, HCV, and NAFLD, chemical … Read More

Research on the Effects of Hormone Changes on Long-Term Prognosis and Intervention Strategies in Adolescent Depression

Xin Sheng

pp.34-38 DOI: 10.62051/3ddeh758

Abstract: This review aims to investigate the impact of hormonal changes on the long-term outcomes and intervention strategies in adolescent depression. In recent years, the incidence of adolescent depression has risen significantly. Its pathological mechanisms are not only related to family and social factors but also closely tied to dynamic hormonal changes during adolescence. Fluctuations in hormone levels, including adrenaline, thyroid hormones, and cortisol, significantly affect adolescents' … Read More

Evaluating the Efficacy of Immune Checkpoint Inhibitors Across Different Cancer Types: Focusing on Lung Cancer, Breast Cancer and Melanoma

Nuoyang Jia

pp.39-44 DOI: 10.62051/8hkm3p85

Abstract: Lung cancer, breast cancer, and melanoma are three of the most studied cancers at the moment due to their high incidence and mortality rates. Recently, immune therapies, especially immune checkpoint inhibitors (ICI) drugs, are being studied and developed to cope with these cancers. Clinical trials have shown significant improvements in cancer treatments after using the ICI drugs including PD-1/PD-L1 and CTLA-4 inhibitors. This review covers the efficacy of using different ICI drugs in treating … Read More

Immunotherapy Targeting HER2-positive Breast Cancer

Chingman Tan

pp.45-52 DOI: 10.62051/z2t4ee06

Abstract: Breast cancer with HER2-positive status is highly invasive and susceptible to recurrence and metastasis, and its targeted immunotherapies mAb (e.g., trastuzumab, pertuzumab), ADCs (e.g., T-DM1, T-DXd), and ICIs have enhance the prognosis; however, their drug-resistance and adverse effects still limit their long-term efficacy. Despite advances in immunotherapy targeting HER2+, the indications for ICIs in HER2-positive breast cancer are unclear, the selection of biomarkers for combination therapy … Read More

Assessment of the Potential of Cardiac Glycosides as New Stars in Cancer Treatment

Yixuan Li

pp.53-58 DOI: 10.62051/fam03r49

Abstract: Cancer is a critical burden to global health. Cardiac glycosides (CGs), a kind of cardiac drug, have been proven to have therapeutic effects for a variety of tumors. However, directly using conventional CGs to treat cancer will lead to dispensable cardiotoxicity. CGs work by inhibiting the Na+ /K+ -ATPase, STAT 1 and STAT 3. It can also block the tumor cell cycle. By doing comparison, it can be known that the anticancer potential of UNBS1450 01 is comparable to that of paclitaxel while the … Read More

Evaluation of the Application Value of Optogenetics Technology in the Development of Immunotherapy Methods for Tumors

Huishan Chen

pp.59-63 DOI: 10.62051/e15j8a18

Abstract: In the field of tumor treatment, traditional methods have limitations, and tumor immunotherapy has become an important direction. As a cutting-edge discipline, optogenetics has been widely explored for application in tumor immunotherapy, such as regulating the activity of immune cells and influencing the tumor-related nervous system. However, there are still deficiencies in the application of this technology in tumor immunotherapy, such as the specific expression of photosensitive proteins and … Read More

Immunological Insights and Translational Advances in HSV-2 Infection and Vaccine Development

Yumin Min

pp.64-70 DOI: 10.62051/z1hazg32

Abstract: Herpes simplex virus type 2 (HSV-2) is a globally prevalent sexually transmitted infection, affecting an estimated 491 million people worldwide. The virus establishes lifelong latency in the sensory nervous system, particularly the sacral dorsal root ganglia, and periodically reactivates to cause recurrent genital lesions, asymptomatic viral shedding, and considerable psychological distress. HSV-2 infection also facilitates HIV acquisition by disrupting mucosal barriers and enhancing the … Read More

Optimizing CAR-T Therapy through CRISPR technology

Yuchen Liu

pp.71-76 DOI: 10.62051/ma2f5v65

Abstract: Cancer continues to be the leading cause of death worldwide, driving an urgent need for effective and precise therapeutic strategies. The combination of CRISPR-Cas9 gene-editing technology with chimeric antigen receptor T-cell (CAR-T) therapy has represented a breakthrough in cancer treatment. This paper offers an in-depth overview of the application of CRISPR technology in enhancing CAR-T therapy. Through targeting and disrupting genes such as TRAC and B2M in T cells, universal CAR-T cells are … Read More

Recent Development in NSCLC Immunotherapies: Mechanisms, Advantages and Research Findings

Jun Gu

pp.77-82 DOI: 10.62051/drgng326

Abstract: The NSCLC is a severe and common chronic disease in the whole world, and it has high mortality, which threatens human life. Therefore, the treatment of NSCLC is a hot topic in both society and the medical field. Nowadays, the treatment of NSCLC has many choices, for example, chemotherapeutic agents and radiotherapy drug treatments, these treatments of NSCLC are limited and have a lot of side effects to the patients, like unavoidable vomiting, hair loss, etc. The immunotherapist is the latest … Read More

Applications of Artificial Intelligence in Cancer Precision and Personalized Medicine

Shili Sun

pp.83-88 DOI: 10.62051/6zv3ry94

Abstract: Artificial Intelligence (AI), as a rapidly evolving technology, is fundamentally transforming the diagnosis and treatment of cancer. This article systematically discusses the research and application progress of AI in key areas such as medical image analysis, genomic data interpretation, personalized treatment design, and clinical decision support. In medical imaging, AI, powered by deep learning, significantly enhances the sensitivity and accuracy of tumor detection in CT, MRI, and other scans, … Read More

Biological Characterization of iPSCs and Its Applications

Feiyuan Zheng

pp.89-93 DOI: 10.62051/ptr6rb77

Abstract: Induced pluripotent stem cells (iPSCs) are pluripotent stem cells obtained by reprogramming somatic cells with transcription factors (e.g., OCT4, SOX2, KLF4, c-Myc), and have self-renewal and differentiation potentials similar to embryonic stem cells (ESCs). Their pluripotency allows differentiation into various cell types, maintained by core transcription factors and regulated by signaling pathways. Different species' iPSCs need specific culture conditions. iPSCs can self - renew through … Read More

Lung Cancer Pathogenesis and Therapeutic Advances

Yupei Zhang

pp.94-98 DOI: 10.62051/3p38v941

Abstract: Lung cancer is the leading cause of cancer-related death globally, killing 1.8 million in 2020. In the US, its mortality exceeds that of prostate, breast and colorectal cancers. Tobacco and air particles drive it. China's male smoking rate and PM2.5 risks are examples. Regional disparities are huge, like in East Asia and Africa. Pathogenesis involves six core mechanisms: Tobacco carcinogen-induced DNA damage (85% population-attributable risk), PM2.5/radon genotoxicity, Somatic driver mutations … Read More

Application and Future Development of Metal Stable Isotopes in Tumor Therapy

Zihan Xu

pp.99-105 DOI: 10.62051/mq1nse28

Abstract: As tumor treatment technology continues to innovate, the medical community is urgently seeking diagnostic and therapeutic methods that are both safe and sensitive. Metal stable isotopes, with their unique properties of non-radioactivity, traceability, and close relationship with human metal metabolism, are becoming a potential new star in precision medicine. Unlike traditional imaging or blood markers, they reflect the cellular environment and pathological state through subtle changes in isotope … Read More

Cancer Immunotherapy: Review, Advancement and Future Outlook

Zizhao Zhang

pp.106-112 DOI: 10.62051/q5rcfr23

Abstract: With the continuous improvement of cancer treatment, numerous approaches have achieved remarkable results and have been implemented in clinical treatment. During the few decades, surgery, radiotherapy, chemotherapy and immunotherapy for cancer therapy were created and developed. Immunotherapy for cancer has played a significant role especially. Tumor cells are adept at employing various mechanisms to evade the attack of the immune system. Therefore, cancer is currently one of the most difficult … Read More

Application of Resting-State fMRI in Auxiliary Diagnosis of Dissociative Disorders: Advances in Cerebral Biomarker Research and Clinical Implications

Yitian Yuan

pp.113-117 DOI: 10.62051/7gbv0a19

Abstract: Dissociative disorders (DDs), a group of trauma-related psychiatric conditions, are characterized by disruptions in consciousness, memory integration, identity coherence, and perceptual continuity. These disorders present significant diagnostic challenges due to symptom overlap with other psychiatric conditions and the lack of objective biomarkers. Resting-state functional magnetic resonance imaging (rs-fMRI), a non-invasive neuroimaging modality, has emerged as a transformative tool for … Read More

Virtual Connection and Real Alienation: A Psychological Path Analysis of the Effect of Cell Phone Use Intensity on Loneliness - With Realistic Social Avoidance as a Mediating Variable

Yanfei Zhu

pp.118-124 DOI: 10.62051/76n02295

Abstract: As the penetration rate of smartphones continues to rise, the psychosocial issues stemming from cell phone dependency are becoming increasingly evident. Existing research has primarily concentrated on the influence of emotional factors, such as social anxiety, in the connection between the intensity of cell phone use and feelings of loneliness. Moreover, the mechanisms at the behavioral level have not been thoroughly examined. This study focused on the behavioral aspect of social avoidance, … Read More

Exploring the Effects of Intimate Relationships on Depression and Anxiety in College Students

Zhe Ding

pp.125-132 DOI: 10.62051/2gk9rz97

Abstract: With growing concerns about university students' mental health, intimate relationships—an essential part of their social lives—play a critical role in shaping emotional well-being. This paper systematically reviews empirical studies to explore the effects of intimate relationship quality on depression and anxiety among college students. Specifically, it examines the mechanisms through which attachment style, emotion regulation strategies, and social support influence psychological outcomes. … Read More

Research Progress on the Influence of People from Childhood Trauma to Fear of Compassion

ZhiLong Cheng

pp.133-136 DOI: 10.62051/3k7msa11

Abstract: Since the 21st century, psychology has gradually developed into a mature and recognized discipline, and mental health problems and mental health care have been paid more and more attention by researchers and patients. Compared with classic psychological themes such as depression and bipolar disorder, compassion and fear have received relatively little attention and research. Moreover, there is ample research evidence that most adults have experienced childhood trauma at some point. However, fear … Read More

Analyzation of the Influence of Video Games on Young People’s Social Satisfaction

Shixin Zheng

pp.137-141 DOI: 10.62051/t6apks73

Abstract: In recent years, with the rapid development of digital entertainment technologies and the increasing sophistication of storytelling in interactive media, video games have evolved beyond mere leisure activities to become complex social and psychological spaces. The parasocial interaction (PSI) between players and game characters is becoming increasingly significant. As a one-way emotional connection, PSI might affect the player's psychological experience and social behaviours. Through … Read More

The Impact of Artificial Intelligence Tools on College Students' Academic Self-efficacy

Xinyu Chen

pp.142-148 DOI: 10.62051/4sgyh834

Abstract: With the continuous development of artificial intelligence technology, its impact on higher education teaching has attracted more and more attention. In particular, the question of whether there is a correlation between the use of artificial intelligence software and the academic self-efficacy of college students and what the related factors are is worthy of in-depth exploration in various fields. Based on the questionnaire survey, this study uses logistics regression analysis to analyze data, … Read More

Exploring the Mechanisms of Déjà Vu: Neurological and Psychological Perspectives

Ziqin Xu

pp.149-154 DOI: 10.62051/yg1j8434

Abstract: Déjà vu, a French term meaning "already seen," refers to the perplexing sensation that a current experience has been encountered previously, despite a definitive lack of such an occurrence. This subjective feeling of familiarity, often accompanied by a simultaneous awareness that the familiarity is misplaced, affects approximately 60-70% of the population and is more prevalent in younger individuals, suggesting a potential link to developmental or cognitive processes. However, there is … Read More

Personalized Neoantigen Vaccines and CAR-T Cell Therapy: A New Frontier in Cancer Immunotherapy

Langyan Zhu

pp.155-162 DOI: 10.62051/qqj4sm14

Abstract: Cancer immunotherapy has achieved groundbreaking successes with strategies like immune checkpoint inhibitors, yet many solid tumors evade immune control. Personalized neoantigen vaccines offer a new level of precision by targeting tumor-specific mutations, thereby inducing highly specific T cell responses against cancer with minimal off-target effects. Chimeric antigen receptor (CAR) T cell therapy has revolutionized treatment of hematologic malignancies, attaining remarkable remission rates, … Read More

Advances and Challenges in CAR-NK Cell Therapy for Tumor Immunotherapy

Bohan Liu

pp.163-169 DOI: 10.62051/mgz9kz72

Abstract: The root cause of tumors lies in genetic mutations. NK cells have shown significant potential in tumor immunotherapy. NK cells possess three anti-tumor mechanisms: direct cytotoxicity, antibody-dependent cell-mediated cytotoxicity, and secretion of cytokines. Compared with traditional αβ T cell therapy, NK cell therapy is safer, and KIR mismatch can enhance its anti-tumor response. CAR-NK cell therapy, through genetic engineering, transfers the synthetic receptor protein CAR into NK cells, … Read More

Circadian Regulation of the Immune System and Susceptibility to COVID-19

Zitong Zeng

pp.170-176 DOI: 10.62051/wemwd548

Abstract: Circadian rhythms regulate essential physiological processes, including immune responses, and their disruption has been implicated in increased vulnerability to infectious diseases. The importance of circadian health has been highlighted by the COVID-19 pandemic, with studies showing that an infection from SARS-CoV-2 can disturb circadian regulation via changes in clock gene expression and the increase of systemic inflammation. Behavioral changes during the pandemic have worsened circadian … Read More

Effect of Music on the Brain’s Memory Processes

Xinhui Wen

pp.177-182 DOI: 10.62051/78vctw34

Abstract: Extensive research has been conducted on the effects of music on memory. However, results have varied regarding the specific impacts of music on cognitive processes. This paper synthesizes predominantly positive results from research on music’s impact on various brain regions and its therapeutic applications, highlighting how listening and playing music can enhance well-being and boost overall cognitive and emotional health. These findings show that music alters the neurological connections in … Read More

Efficacy and prognosis of different interventional psychiatric treatments for patients with severe depression

Yuze Lai, Jichong Zhou

pp.183-187 DOI: 10.62051/ygt4nv07

Abstract: This review examines the efficacy and prognosis of various interventional psychiatric treatments for patients with severe depression. Major depressive disorder (MDD), characterized by persistent low mood and loss of interest, is a significant global health issue, particularly prevalent among younger populations and exacerbated by the COVID-19 pandemic. Despite the availability of multiple pharmacological, psychotherapeutic, and specialized physical treatments for MDD, the overall prognosis … Read More

The Impact of Learning Environment on Students' Procrastination Behavior and Learning Efficiency

Miaohan Yu

pp.188-193 DOI: 10.62051/g2ykr082

Abstract: In the fast-paced modern learning environment, procrastination significantly impacts students' learning efficiency and can lead to psychological issues such as depression and anxiety. This study is aimed at the effect of learning environment on students' procrastination behavior and learning efficiency. Researcher adopted questionnaire survey to collect the data among junior and senior high school students. The General Procrastination Scale (GPS) was used to measure procrastination levels. The … Read More

Analysis of the relationship between deferred examination and test anxiety among Chinese college students: an empirical study based on South China Normal University

Changqi Yu

pp.194-201 DOI: 10.62051/gs61pp56

Abstract: In contemporary Chinese society, there is generally greater academic stress and higher levels of test anxiety among college students. Some studies have explored the causes and effects of test anxiety. However, seldom scholar has discussed the relationship between deferred examination and test anxiety. This study is aimed to investigate the relationship between deferred examination and test anxiety among Chinese college students. In this study, 113 valid samples were collected through an online … Read More

Traditional and Recurrent Spheno-Orbital Meningioma (SOM) Comparison and Treatment Methods

Xuanyu Liu

pp.202-207 DOI: 10.62051/q186ws19

Abstract: Spheno-orbital meningiomas (SOM) are rare brain tumors that pose significant challenges to treatments due to their anatomical complexity and high recurrence rates. This literature review considers journals published between 2000 and 2024. Analysis will be drawn based on current surgical and nonsurgical interventions of primary and recurrent SOMs and emerging treatments. Besides that, the review will draw an in-depth description of genetic mutations, such as NF2 and PI3K/AKT/mTOR pathway … Read More

The Impact of Sibling Presence on Individual Social Competence

Ziyi Yang

pp.208-213 DOI: 10.62051/kstnf592

Abstract: This study examines how the presence of siblings affects adolescents' social competency, which is a crucial aspect of personal socialization. Motivation, knowledge, and social skills are all components of social competency, which is necessary for productive interpersonal relationships. The study examines how peer and family influences impact social development, with a particular emphasis on sibling dynamics, drawing on the body of previous work. Sixty-three Beijing high school students were … Read More

The Relationship Between Negative Experiences In Childhood And Mental Health

Tianqi Xie

pp.214-219 DOI: 10.62051/hv04g925

Abstract: In recent years, the prevalence of mental illnesses such as depression and bipolar disorder among Chinese adolescents has shown an increasing trend. Therefore, this issue has received significant attention from all sectors in China. Given that childhood is a crucial stage in individual development, poor mental health can affect the mental well-being of adolescents. Thus, this study analyzes the risk factors for adolescent mental illness, including physical constitution, family factors, and … Read More

Correlation Between Peer Pressure And Learning Efficiency

Lingyi Qiao

pp.220-225 DOI: 10.62051/m566gp12

Abstract: In the current educational environment, the "involution" culture which is a state of excessive competition and irrational internal consumption is spreading rapidly among high school students, and the impact of peer pressure on students' learning efficiency has become an important topic. This survey aims to explore the relationship between peer pressure and learning efficiency among high school students. A survey was conducted on high school students. To ensure the scientific rigor of the … Read More

A Review of the Neurobiological Mechanisms and Treatment Options of ADHD Across Different Age Groups

Yixuan Li

pp.226-230 DOI: 10.62051/xyne9159

Abstract: This review paper synthesizes academic research to explore various aspects of ADHD, including its neurobiological mechanisms involving the basal ganglia, prefrontal cortex (PFC), and the roles of neurotransmitters such as dopamine and norepinephrine. It also examines how treatment approaches for ADHD vary across different age groups, emphasizing the need for special consideration in specific age groups, such as preschool children and older adults, due to factors like medication tolerability and … Read More

Neural Mechanism and Educational Interventions for Children with ADHD: From Brain Science to Classroom Practice

Runyao Wang

pp.231-237 DOI: 10.62051/m8wgf949

Abstract: Attention deficit hyperactivity disorder (ADHD) is one of the most common neurodevelopmental disorders in childhood, and its characteristic symptoms include inattention, hyperactivity, and impulsive behavior, which seriously affects patients' cognitive function, academic performance, and social adaptability. This paper systematically reviews the etiological mechanisms, behavioral manifestations and educational intervention strategies of ADHD, integrating research progress in neuroscience and … Read More

Treatment For Anterior Cruciate Ligament (ACL) Injury

Ke Xu

pp.238-241 DOI: 10.62051/4g9bh689

Abstract: Anterior cruciate ligament (ACL) injuries are one of the most common injuries in basketball, soccer, and other adversarial sports. This article explores the complex epidemiologic patterns of ACL injuries (especially among female and youth athletes) and the various diagnostic tools used to identify ACL tears. Both conservative and surgical treatment options are highlighted, with attention to the rehabilitation process and psychological factors affecting recovery. The paper also highlights the … Read More

Application Of Traditional Chinese Medicine In The Field Of Prevention And Treatment Of Influenza A

Sutong Li

pp.242-248 DOI: 10.62051/v9kaej46

Abstract: Traditional Chinese Medicine (TCM) has demonstrated multifaceted therapeutic potential in the prevention and treatment of H1N1 influenza (swine flu), leveraging its antiviral, immunomodulatory, and anti-inflammatory properties. Studies highlight the efficacy of classic formulations such as Yinqiao San (Honeysuckle and Forsythia Powder) and Yupingfeng San (Jade Screen Powder) in alleviating symptoms (e.g., fever, cough), shortening disease duration, and reducing complications.  Active compounds … Read More

The Mechanism Of Action Of EGFR In Cancer Development And Targeted Therapy And Its Optimization Strategy

Lexin Jin

pp.249-253 DOI: 10.62051/gqd8xy95

Abstract: The incidence of cancer has continued to rise, particularly among the elderly population with mortality rates surpassing those of other diseases, drawing significant societal attention. The causes of cancer are complex with approximately 5% linked to genetic factors, while studies on the correlation between histone modifications and mutation rates reveal potential differences in germline and somatic cells. The EGFR a receptor tyrosine kinase on the cell membrane is closely associated with the … Read More

Molecular Diagnostic Approaches For Sickle Cell Anemia

Wenbo Huan

pp.254-259 DOI: 10.62051/ecqw0s89

Abstract: Sickle cell anemia (SCA) is a common genetic disease caused by gene mutations, affecting a large population worldwide, with newborns accounting for up to 79%. With the continuous development of molecular biology and molecular diagnostic technology, a variety of molecular diagnostic methods have been widely used in clinical practice in recent years, including polymerase chain reaction (PCR), high-resolution melting curve analysis (HRM), Sanger sequencing, next-generation sequencing (NGS), and … Read More

Risk Factors, Pathophysiology, And Treatments Of Acute Ischemic Stroke

Boyu Xie

pp.260-265 DOI: 10.62051/rcyr7n30

Abstract: The acute ischemic stroke has a high mortality, resulting in high importance of its information. The treatment of acute ischemic stroke still needs more effective therapy, and society needs more attention on this disease. This paper reviews the past research and statistics on risk factors, pathophysiology, and treatments of the acute ischemic stroke. For the risk factors, some of the factors are related to the lifestyle in modern society, and some of the factors are medical and biological … Read More

Advances In The Research And Application Of Cytokines In Human Cancer Treatment

Xuanlin LU

pp.266-274 DOI: 10.62051/b30z9h90

Abstract: Cancer surgery and radiotherapy usually fail to achieve long-term remission due to toxic effects, and tumors remain a major global health burden, while traditional therapies such as chemotherapy have problems with recurrence and immune escape. In recent years, immunotherapy has attracted much attention as a promising alternative therapy, among which cytokines play a key role in regulating anti-tumor immunity. Advances in cytokine biology and bioengineering have promoted the development of … Read More

Current Status Of Immunotherapy For Cervical Cancer

Yibao Yu

pp.275-281 DOI: 10.62051/s99byb48

Abstract: Cervical cancer is one of the common gynecological malignancies that threaten women's health. Its etiology is complex, among which persistent human papillomavirus (HPV) infection is the main pathogenic factor. Due to the lack of obvious early symptoms, many patients are already in the middle and late stages when diagnosed. Although conventional chemotherapy can alleviate the disease, some patients will still experience recurrence or metastasis, indicating that the existing treatment methods are … Read More

Computational Optimization Of Purmorphamine-Derived Small Molecule Modulators Targeting The Secretin Receptor (SCTR) For Antihypertensive Therapy

Yuhao Xi

pp.282-289 DOI: 10.62051/ggrvpv67

Abstract: Hypertension remains a global health problem. Although existing treatments (such as ACE inhibitors, β-blockers, etc.) are widely available, their side effects and patient compliance issues limit the therapeutic effect. Therefore, the development of new small molecule drugs is particularly important. This study targets pancreatic cholinergic receptors (SCTR), which play an important role in vasodilation and blood pressure regulation and have the potential to become a new target for … Read More

Engineering Strategies And Therapeutic Applications Of In Vivo Anti-Tumor Gene Delivery Platforms

Yuan Liu

pp.290-297 DOI: 10.62051/mdt4x187

Abstract: Gene therapy for cancer has received extensive attention in recent years. Adeno-associated virus (AAV), messenger RNA delivered by lipid nanoparticles (mRNA-LNP), and oncolytic viruses (OVs) are the three most actively studied delivery platforms. The three have different advantages in anti-tumor factor expression, immune activation, and targeting ability. Current research has made positive progress in animal models and preclinical experiments, but there are still obvious challenges in delivery … Read More

The Relationship Between Diet And Cardiovascular Diseases And The Application Of Dietary Patterns In Treatment

Ximeng Yang

pp.298-303 DOI: 10.62051/0ng5kt06

Abstract: Cardiovascular diseases (CVDs) remain the leading cause of death worldwide, with diet playing a major role in their development and prevention. In recent years, growing research has highlighted the importance of overall dietary patterns, rather than isolated nutrients, in influencing heart health. Studies have shown that diets rich in whole foods, healthy fats, and plant-based ingredients can significantly reduce cardiovascular risk, while diets high in sugar and processed foods increase it. … Read More

Pathogenesis And Treatment Of Rheumatoid Arthritis Based On Inflammation

Jinwen Zhu

pp.304-309 DOI: 10.62051/gtr99058

Abstract: Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by persistent synovitis and joint destruction. Its pathogenesis involves complex interactions between genetic, environmental and immune system factors. In recent years, JAK/STAT and NF-κB signaling pathways have become the focus of research due to their central role in pro-inflammatory factor expression and immune cell activation. The continuous activation of JAK/STAT pathway can further aggravate inflammation and bone … Read More

Mechanism And Application Status Of CAR-T Cell Immunotherapy

Yunuo Liu

pp.310-314 DOI: 10.62051/p6afxj50

Abstract: With the continuous increase in the incidence and mortality of cancer, finding more accurate and effective treatment methods has become an important direction of medical research. As an important technological breakthrough in the field of tumor treatment in recent years, chimeric antigen receptor T cell (CAR-T) immunotherapy transforms T cells through genetic engineering to enable them to specifically recognize and kill tumor cells, overcoming many limitations of traditional treatment methods … Read More

Research Status And Development Trend Of Monoclonal Antibodies For Non-Small Cell Lung Cancer

Minghui Gao

pp.315-319 DOI: 10.62051/hg0b7s02

Abstract: Lung cancer remains the leading cause of cancer-related mortality globally, with non-small cell lung cancer (NSCLC) accounting for 80% of cases. Traditional chemotherapy faces limitations such as non-specific cytotoxicity, transient efficacy, and resistance due to tumor heterogeneity. Monoclonal antibodies (mAbs) have emerged as transformative agents, offering targeted therapy with improved specificity and reduced toxicity. Recent advancements include immune checkpoint inhibitors anti-angiogenic … Read More

Effect of Resveratrol on Major Gynecological Tumors

Renqin Wang

pp.320-325 DOI: 10.62051/cjavpy18

Abstract: Breast cancer (BC), cervical cancer (CC), endometrial cancer (EC), and ovarian cancer (OC) are the four most common tumors in women, which seriously threaten women's lives. However, the current mainstream treatment approaches are accompanied by great side effects, and related drugs are scarce. In recent years, researchers have discovered that RES has multiple biological functions and can intervene in the occurrence and development of common gynecological tumors through various pathways, such as … Read More

Bridging Traditional Wisdom and Modern Diagnostics: Optimizing Chronic Kidney Disease Management through Technological Integration of Traditional Chinese Medicine and Western Medicine

Shiqi Lan

pp.326-336 DOI: 10.62051/xp77ha77

Abstract: Chronic kidney disease (CKD) is a major and increasing issue for public health around the world and places a heavy burden on healthcare systems globally. Current western medical (WM) treatments are relatively developed but still face difficulties in stopping the advancement of the disease and addressing the complete and complicated symptomatology of the disease at later stages. Meanwhile, the use of traditional Chinese medicine (TCM) that comes with a whole-istic philosophy and rich experience … Read More

Advances in Immunotherapy of Biomarkers for Non-small Cell Lung Cancer Based on Radiomics

Yifei Deng

pp.337-343 DOI: 10.62051/nscfth04

Abstract: With the development of immunotherapy for non-small cell lung cancer (NSCLC), it has become increasingly crucial to evaluate the efficacy of immunotherapy and screen for the beneficiary population. However, how to use radiomics to screen suitable immune checkpoint markers and analyze immunotherapy prognosis is still lacking in-depth research. In this study, the basic concepts of radiomics were explored and biomarkers were analyzed in combination with computed tomography (CT) and positron … Read More

Transplantation of Hematopoietic Stem Cells in Tumor Therapy

Jiefu Deng

pp.344-348 DOI: 10.62051/2v4ts794

Abstract: Hematopoietic stem cell transplantation therapy (HSCT) has achieved remarkable results in the treatment of various malignant tumors, especially leukemia and other hematologic diseases. However, it still faces some problems in clinical application. They mainly include graft-versus-host disease (GVHD), transplantation-related mortality (TRM), difficulties in donor matching, risk of disease recurrence, and high treatment costs and technical requirements. However, with the recent development of … Read More

Progress in the study of drug resistance mechanism of Salmonella

Ruoyao Liu

pp.349-356 DOI: 10.62051/8gvg6f43

Abstract: Foodborne Salmonella is a Gram-negative bacteria that is widely spread globally and is capable of causing typhoid fever, paratyphoid fever, and poisoning in the human body. Meanwhile, Salmonella is one of the four leading causes of diarrheal diseases worldwide. More and more reports indicate that the status of Salmonella resistance to antibiotics is not optimistic. Studies have shown that the resistance mechanisms of Salmonella is related to enzyme inactivation, efflux pumps, removable … Read More

Addressing Antimicrobial Resistance: Evidence-Based Strategies And Innovations

Wenrui Jiang

pp.357-364 DOI: 10.62051/aa0wrb89

Abstract: Antimicrobial resistance (AMR) is a significant global public health challenge, involving complex interactions across medical, environmental, economic, and social domains. This study integrates multidisciplinary perspectives, utilising literature reviews and case analyses to examine the current state and challenges of AMR, critique the limitations of existing strategies, and propose innovative solutions based on cutting-edge research. The study finds that environmental resistance genes, as … Read More

Potential And Challenges Of Phage Therapy: An Alternative Strategy In The Post-Antibiotic Era

Xin Wang

pp.365-376 DOI: 10.62051/qbmd3g34

Abstract: The surge in antibiotic resistance has positioned phage therapy as a focal point in global medical research. This paper systematically explores the potential and challenges of phage therapy as an alternative strategy in the post-antibiotic era, integrating the research results from the past five years both domestically and internationally, analyzing their biological mechanisms, clinical application value, and bottlenecks for industrialization. Studies have demonstrated that phages exhibit … Read More

Advances In The Application Of Click Chemistry In The Research Of Targeted Therapeutic Drugs

Yue Zhang

pp.377-382 DOI: 10.62051/y0yezt68

Abstract: Click chemistry has become an important tool in the research of targeted therapeutic drugs due to its high efficiency, specificity and mild reaction conditions. Cancer, as one of the major diseases that endanger human health, urgently needs more accurate and efficient treatment methods. Traditional targeted therapeutic methods have the problems of poor selectivity and easy to cause serious side effects, while click chemistry significantly improves the specificity and effect of treatment by … Read More

Nature as Medicine: Exploring Health Benefits of Forest Bathing

Yijia Li

pp.383-390 DOI: 10.62051/qr7tvk14

Abstract: The accelerating rate of urbanisation correlates with an increase in mental health issues, including anxiety and depression. While pharmacological treatments remain common, they come with side effects and limited long-term efficacy. In recent years, nature-based interventions, particularly forest bathing (Shinrin-yoku), have received increasing attention for their potential psychological and physiological benefits. However, the application of such nature-based public health strategy remains … Read More

Covalent Inhibitors Targeting FabH: A Cutting-edge Strategy in the Development of Novel Antibiotics

Ruize Zhang

pp.391-396 DOI: 10.62051/gvs2pj23

Abstract: Antibiotic resistance has become a global public health crisis, and there is an urgent need to develop new mechanism antibacterial drugs targeting specific targets of bacteria. β -ketoacyl-ACP synthase Ⅲ (FabH) inhibitors have shown great potential to overcome bacterial resistance and have become an emerging hot field in the research and development of anti-infective drugs. And unlike traditional reversible inhibitors (relying on transient non-covalent interactions), covalent inhibitors can form … Read More

Clinical Progress of Targeted KRAS Drugs Combined with Immune Checkpoint Inhibitors in the Treatment of Pancreatic Cancer

Lu wang

pp.397-402 DOI: 10.62051/rq7x6r98

Abstract: Kirsten Rat Sarcoma Viral Oncogene Homolog (KRAS) is one of the important drivers of pancreatic ductal adenocarcinoma. Although there has been progress in the development of targeted KRAS drugs, single-targeted therapy has limited effects due to the complexity of mutations. Immune checkpoint inhibitors have poor efficacy in common pancreatic cancer patients. Therefore, the combined treatment strategy of the two has attracted attention. By means of the targeted drugs to inhibit the tumor … Read More

Different Rehabilitation Treatment Methods Used at Meniscus Injury

Ruihaoran Wang

pp.403-407 DOI: 10.62051/mfavs698

Abstract: Meniscus injury (MI) refers to a series of clinical symptoms resulting from the structural damage of the meniscus in the knee joint, which is caused by factors such as external forces or degeneration. This study aimed to explore the clinical efficacy and rehabilitation significance of rehabilitation treatment methods, including exercise therapy, physical therapy, and balance training, for patients with MI. By comparing the interventions of multiple rehabilitation treatment methods on MI patients … Read More

The mechanism and effects of traditional Chinese medicine in treating diseases through the regulation of intestinal microbiota

Xiaonan ji

pp.408-412 DOI: 10.62051/kg10ge49

Abstract: Traditional Chinese Medicine (TCM) is a traditional medical system based on natural plants, animals and minerals, emphasizing holistic regulation and treating both symptoms and root causes. In recent years, the role of TCM in regulating the intestinal microbiota has become a research hotspot. By analyzing 80 articles, this paper summarizes the regulatory effects of 48 TCM single herbs or compound preparations on the intestinal microbiota, involving 67 target sites. Among them, core microbiota … Read More

Evolving Paradigms in Low-Template DNA Analysis: From Fixed Analytical Thresholds to Probabilistic Modeling

Yilei Zhao

pp.423-431 DOI: 10.62051/mjbq7s89

Abstract: Inferring conclusions in low-template DNA (LT-DNA) profiles is a very difficult task in forensic genetics. The analytical threshold (AT), which distinguishes allele signals from noise, is the most important parameter for the quality of these profiles. This paper recounts the development of the AT, beginning as a fixed value and progressing to a parameter in complex probabilistic models. It explains how the intrinsic difficulty of LT-DNA, especially the stochastic nature, revealed the … Read More

Deciphering the Neural Circuits of Consciousness: An Integrative Framework from Microcircuits to Global Networks

Jinhong Wu, Man Li

pp.432-440 DOI: 10.62051/kh9n6s25

Abstract: Consciousness arises from dynamic cross-scale interactions, yet its neural substrates remain fragmented across spatiotemporal hierarchies. This review synthesizes pivotal advances from the past five years (2020-2025), integrating perturbational complexity mapping, optogenetic dissection, and multimodal neuroimaging to delineate core mechanisms. Key findings include: (1) thalamocortical reverberations generating conscious-state-specific EEG signatures (e.g., off-period-rebound sequences; (2) … Read More

The Growing Threat of Antibiotic Resistance: A Public Health Crisis

Yuhan Liu

pp.441-447 DOI: 10.62051/p5cqn866

Abstract: Antibiotic resistance is a mounting worldwide health crisis that undermines the very foundations of modern medicine. During these practices, prescription and overprescription of antibiotics in healthcare, noncompliance with the therapy by the patient, mass usage in agriculture, environmental pollution, and the contemporary increment of international travel contribute to the spread of antibiotic resistance. It explores how infectious diseases—particularly in the developing world—share the blame … Read More

Role of Mitochondrial Autophagy in Cell Aging and Its Molecular Mechanism

Xinyi Yang

pp.448-453 DOI: 10.62051/91sfnw58

Abstract: Cell aging is the basis of organism aging, which is closely related to many aging-related diseases. Mitochondria, as the energy factory of cells, its function decline and damage play a key role in the process of cell aging. Mitochondrial autophagy is an intracellular quality control mechanism to selectively remove damaged mitochondria, which can delay cell aging by maintaining mitochondrial function and intracellular homeostasis. This paper reviews the role of mitochondrial autophagy in cell … Read More

Semaglutide as a Novel Therapeutic Agent for Obesity and Type 2 Diabetes

Ruilin Chen

pp.454-459 DOI: 10.62051/5008za94

Abstract: Obesity and type 2 diabetes are becoming more common around the world, creating serious health and economic challenges. There is a growing need for treatments that are not only effective but also safe and easy to use over a long period. In recent years, a group of drugs called glucagon-like peptide-1 agonists （GLP-1RA） has gained attention for their ability to lower blood sugar and support weight loss. One of the most promising of these drugs is semaglutide, which has shown strong results in … Read More

Statistical Analysis of COVID-19 Vaccine Effectiveness:A Retrospective Study Based on Global Data

Zhoujie Xie

pp.460-465 DOI: 10.62051/8b9wcy88

Abstract: The COVID-19 pandemic has led to extensive global vaccination campaigns aimed at reducing infection rates, hospitalizations, and mortality. However, disparities in vaccine distribution and the emergence of new variants have raised concerns about real-world vaccine effectiveness across different populations. This paper evaluates the relationship between vaccination rates and public health outcomes, including infection rates, hospitalization rates, and mortality rates, across 15 countries spanning … Read More

Power of Poop: Identification and Analysis of Gut Microbiome Biomarkers in Diarrhea

Chenxi Hu

pp.466-479 DOI: 10.62051/aw8cvm49

Abstract: The human gut microbiome, a vast collection of billions of bacteria in the gastrointestinal tract, plays a crucial role in maintaining host health through homeostasis. Diarrhea, which affects approximately 179 million people annually, significantly alters the gut microbiome. While infectious diarrhea is characterized by an increase in pathogens such as Escherichia coli, the changes in gut microbiome following non-infectious and chronic diarrhea remain unclear. Recent advances in metagenomic … Read More

Local Polio Eradication Programs in Key Endemic Regions in Pakistan: A Scoping Review

Zayna Ilahi

pp.480-491 DOI: 10.62051/1rpwp517

Abstract: This scoping review aims to identify and map the existing programs deployed in Pakistan to improve polio vaccination rates and understand the factors contributing to the persistent challenges in eradicating the disease. The review followed the Joanna Briggs Institute (JBI) methodology for scoping reviews. A comprehensive search of PubMed was conducted, limited to publications within the last 6 years (2019-2025), yielding 96 publications. Data extraction and synthesis focused on program … Read More

The evolving landscape of cancer-causing viruses and clinical trials for vaccine development

Ruoshui Du

pp.492-500 DOI: 10.62051/bxfbaq66

Abstract: Viral infections cause some of the world's most deadly cancers, including cervical, liver and nasopharyngeal cancers. In this review, we spotlight the major oncogenic viruses (HPV, HBV/HCV, EBV and others) describing their mechanisms of carcinogenesis and pathogenetic impact. With a primary focus on the landscape of vaccine development, we review preventative vaccines that have had broad success in reducing cancer (for HPV and HBV). The study also includes an overview of current Phase I and II … Read More

Research on Transdermal Penetration of Rotigotine Transdermal Patchng

Yuxin Ma

pp.501-507 DOI: 10.62051/50rzxt39

Abstract: The transdermal penetration behavior of drugs is a core link in the research and development of transdermal drug delivery systems, and its efficiency directly affects the in vivo absorption and therapeutic effect of drugs. The selection and processing of skin have an important impact on studying the transdermal penetration behavior of drugs. This study aims to investigate the penetration characteristics of rotigotine transdermal patches in different animal skins (mouse, rat, nude mouse, and pig … Read More

Genetic evidence supporting the causal link between optic neuritis and rheumatoid arthritis

Luyue Zhang, Shuting Liu, Jincheng Guo, Jiayuan Yao, Heyi Zhang, Yiwen Zhang, Ting Cheng, Shengxiao Zhang

pp.508-514 DOI: 10.62051/8typ8n07

Abstract: Background: Previous studies have observed an association between optic neuritis (ON) and rheumatoid arthritis (RA). However, the causal relationship between these two conditions remains ambiguous. This study aimed to explore the causal effect between ON and RA using Mendelian randomization (MR) analysis. Methods: Summary statistics for RA (14,361 RA cases and 43,923 healthy controls (HCs)) and ON (582 cases and 217,491 HCs) were obtained from an available meta-analysis of published genome-wide … Read More

A Personalized Aerobic Exercise Intervention for Chinese Adolescents with Congenital Heart Disease: A Methodological Framework for a Three-Year Longitudinal Study

Zinong Zhu

pp.515-523 DOI: 10.62051/5xfxfc62

Abstract: The population of adolescents with congenital heart disease (CHD) is expanding. With medical advances, the group of people who survive to adolescence with CHD continues to grow. In China, the challenges are further magnified by a sedentary lifestyle as a result of academic pressures and parental over-protection, underscoring how timely exercise interventions that are both safe and efficacious are needed. To meet this need, this paper presents a methodological framework for a three-year … Read More

In Vivo CAR-T Therapy: The Transformational Leap Toward Affordable and Safer Cancer Immunotherapy

Leyang Liu

pp.524-535 DOI: 10.62051/88991486

Abstract: In vivo CAR-T therapy is revolutionizing oncology since it entails modifying a patient's T cells in situ, as opposed to the costly and lengthy ex vivo manufacturing process usually associated with traditional CAR-T therapy. This revolutionary approach utilizes lipid nanoparticles (LNP) or engineered viral vectors (e.g., AAV/LV) to deliver CAR genetic payloads directly to endogenous T cells, greatly reducing production costs while bypassing complex logistics such as leukapheresis and cell … Read More

Development of a PLA-b-PEG Drug Delivery Carrier Design Framework and ROS pH Responsive Methotrexate Carriers for RA

Jiaxuan (Joseph) Fu

pp.536-550 DOI: 10.62051/rbcycj58

Abstract: Methotrexate (MTX) remains the first-line treatment for rheumatoid arthritis (RA), but its clinical use faces substantial challenges due to poor water solubility and systemic side effects. To address these limitations, this study develops a framework for designing polymer-based drug delivery carriers by investigating the relationship between polymer parameters, self-assembly behavior, and pharmacokinetic properties of PLA-b-PEG block copolymers. A multiparameter analysis examined the effects of … Read More

Principles and Applications of Vaccine Design Based on Immune Regulatory Networks

Gujue Chang

pp.551-555 DOI: 10.62051/vmtajp24

Abstract: Vaccinology is shifting from empiricism to rational design rooted in the immune regulatory network. Here we dissect how this network—dendritic cells, T/B lymphocytes, cytokines and their spatiotemporal interactions—can be selectively reprogrammed to control the magnitude, quality and persistence of vaccine responses. After mapping the cellular and molecular checkpoints that decide protection versus tolerance, we show how this insight directs (i) adjuvant selection targeting specific PRR—cytokine … Read More