Degradation and remediation of environmental pollutants by algae

Yike Jing, Qiyu Shen, Meng Zhang, Zhuoxi Han, Wenzheng Zhao

pp.1-10 DOI: 10.62051/bshtwv53

Abstract: The usage of a large number of industrial resources and the discharge of harmful pollutants have caused serious damage to the environment and ultimately affect the ecosystem and human health. Bioremediation is a green, sustainable and low-cost technology for the treatment of environmental pollutants, which includes the process of environmental remediation using plants, animals, microorganisms and so on. Among them, algae have the characteristics of rapid growth, wide distribution, strong stress … Read More

Study on resistance of MdMYB gene family in apple

Chengzhou Wang

pp.11-19 DOI: 10.62051/6jf33z44

Abstract: The growth and development of apples are susceptible to environmental stress. The MdMYB gene family is one of the largest gene families in apples. It is widely involved in various resistance signaling pathways in apples and can interact with a variety of genes. Through anthocyanin synthesis, lignin synthesis, epidermal wax synthesis, Na + / H + pump regulation, hormone interaction, etc., the resistance of plants to abiotic and biotic stresses is improved. The MdMYB gene is regulated by multiple … Read More

The Effect and Potential Mechanism of Microbiota in Major Depressive Disorder

Yong Jiang

pp.20-27 DOI: 10.62051/qr5j3s93

Abstract: Nowadays, Major depressive disorder is a global mental illness, for which antidepressant treatment with traditional drugs in the past is not effective. Gut microbiota (GM) plays a vital role in depression. The diversity of GM differs between patients inflicted with major depressive disorder and normal people. Besides, GM disorder is closely related to depression severity. This study found that anxiety as the clinical manifestation of major depressive disorder is highly intertwined with GM. There … Read More

Study on Microbial Degradation Characteristics of Diesel Contaminated Soil

Weitao Liu

pp.28-34 DOI: 10.62051/44ny6x26

Abstract: A novel and highly effective Acinetobacter (L15) were obtained from soil by morphological observation, physiological and biochemical tests and 16 SrDNA sequencing. The optimal reaction environment of L15 at different temperatures was determined by shaking test, and the catalytic activity was measured. It was found that the bacteria could withstand n-cetane value above 5000 mg/L when the initial culture pH was 7, the inoculation amount was 5%, the shaking speed was 150 r/min, and the culture … Read More

A Review: The Role of Functional Groups in the Binding of Acetylcholine and Nicotine to Muscle-type nAChRs

Yihan Xu

pp.35-40 DOI: 10.62051/b4fcdq66

Abstract: This essay discusses the different affinities of acetylcholine and nicotine for muscle-type acetylcholine receptors (nAChRs) due to their different chemical structures and binding mechanisms. Muscle-type nAChRs are pentameric receptors composed of five protein subunits, with the alpha subunit directly interacting with acetylcholine or nicotine. Acetylcholine binds to muscle-type nAChRs through key functional groups, including the carbonyl group and the quaternary ammonium cation, and specific … Read More

Investigating Human Expectancy by Linear Regression

Linhui Gao

pp.41-45 DOI: 10.62051/4bkv9m17

Abstract: In recent years, many people have studied the human lifespan, some people study how to extend the human lifespan, explore the limits of the human lifespan, and so on. But what are the factors that affect human lifespan, and will they lead to an increase or decrease in lifespan? This paper was analyzed by using linear regression, where specific analyses were performed using R- square and multiple R, mainly studies the influence of three factors, BMI, Schooling, and HIV/AIDS, on human life … Read More

Ω-3 PUFA DHA: Benefits Associated With Brain

Wenxuan Chen

pp.46-49 DOI: 10.62051/z3e6f320

Abstract: DHA and EPA from fish oil are ΩΩ-3 polyunsaturated fatty acids which can’t be synthesized adequately in human body as the conversion from ALA and ARA is low. Thus, we can only get the recommended dose from marine animals and supplements at the natural ratio. Notably, global warming is predicted to decrease availability of this nutrient, and part of its role in the human body cannot be seen in the form of supplements. This review article summarizes the benefits of DHA on fetal development … Read More

A review focus on the latest research progress of vitamin D in brain science

Ziming Liu

pp.50-54 DOI: 10.62051/b7d34840

Abstract: Vitamin D is a hormone precursor that is increasingly recognized for its broad impact, including on brain health. Vitamin D regulates neurotrophic growth factors and influences inflammation and thrombosis; all of which affect neurocognition. Lack of vitamin D can cause osteoporosis, decreased bone density, and fractures. The flesh of fatty fish and fish liver oils are the finest sources of vitamin D. Any mixture of calcifediol, obtained from vitamin D3, and ercalcidiol, derived from vitamin D2, … Read More

Biological reasons for the phenomenon of eating disorders are more prevalent in the female population

Vera Zhang

pp.55-60 DOI: 10.62051/fkfh1k77

Abstract: Eating disorders, characterized by irregular eating habits and distress concerning body image, have emerged as a significant global health challenge. With a specific focus on gender disparities, this paper explores the complex interplay of biological, environmental, and psychological factors contributing to the prevalence of eating disorders like anorexia nervosa, bulimia nervosa, and binge-eating disorder. The paper delves into evolutionary theories, arguing that historically ingrained … Read More

Study on the Therapeutic Effect of shRNA Injected into Tail Vein on Parkinson’s Disease in Mice Based on SNCA Gene Mutation of α-Synuclein

Yutong Zhang, Xiuzhi Dai

pp.61-65 DOI: 10.62051/9ce7yb40

Abstract: Aim: This research aims to investigate the therapeutic effect of shRNA injected into the tail vein on Parkinson’s disease in mice based on SNCA gene mutation of α-synuclein and explore the migration mechanism of α-synuclein. Methods: SCNA +/+ mice are used to induce α-synuclein by tuberculin pff and then establish the model of Parkinson’s disease in mice. Besides, AAV-shRNA is used to set the control group and the experimental group at different times. Open-field test, tail suspension test, and … Read More

A brief review on the history of classic genetics

Ruizhen Xu

pp.66-71 DOI: 10.62051/h5w4p511

Abstract: As we gain more knowledge about gene, DNA and inheritance, we began to understand that proper control of gene expression is the one of the most important aspects of life. This paper conducts a brief review on the history of classic genetics, helping people gain more knowledge about genes, DNA, and genetics. Read More

Drug-Induced Neurotoxicity Mechanisms Underlie Addiction Symptoms

Xinyi Hu

pp.72-81 DOI: 10.62051/rtky6505

Abstract: The molecular mechanisms contributing to substance use disorder (SUD) have gained significant attention in recent years. In the last decade, people have found that addiction is hardly a decision of willpower but can be attributed to multiple molecular changes occurring in the brain after repeated drugs administration. The current research is focusing on understanding the mechanisms through which drugs administrations modify the brain and cause addicted individuals to become more susceptible to … Read More

Detection of Feline Cupripoxvirus and Variation Analysis of Its VP1 Gene in Chengdu from 2020 to 2023

Xining Jia, Bin Zhang

pp.82-88 DOI: 10.62051/ctwdy981

Abstract: Feline calicivirus (FCV) is an important pathogen causing infectious diseases in the oral cavity and upper respiratory tract of cats. Research on its prevalence and genetic variations contributes to the prevention and treatment of related diseases, as well as the development of new vaccines. In this study, a total of 113 samples of eye, nose, and throat secretions were collected from cats with respiratory and oral inflammation symptoms in Chengdu area from 2020 to 2023. The samples were tested … Read More

(Poly)phenol-rich food and cardio-metabolic health

Yu Hu

pp.89-96 DOI: 10.62051/4pt2w058

Abstract: Due to the changes in people's diet structure caused by economic development, cardio-metabolic disease has also become a concernthat more people care about or need to alleviate. (Poly)phenols, a chemical widely found in natural plants or fruits, such as, berries and tea, are thought to play an important role in alleviating cardiometabolic disease. As a result, (poly)phenols rich foods can offer positive effects in general cardiovascular system, and multiple evidence present in helping improve … Read More

Blood Lipids and Cardiovascular Disease: A Mendelian Randomization Study

Jingran Wang

pp.97-105 DOI: 10.62051/qamtcg89

Abstract: Blood lipids have been considered critical risk factors for cardiovascular disease (CVD). The causal relationship between blood lipids (HDL-C, LDL-C and triglycerides) and cardiovascular disease remains uncertain despite negative and positive associations observed in observational studies, which are susceptible to confounding and reverse causation. This study aimed to investigate the potential causal relationship between the three types of blood lipids and CVD using a two-sample Mendelian … Read More

How successful are some existing vaccinations in preventing COVID?

Zhichen Lu

pp.106-113 DOI: 10.62051/2sf0rs31

Abstract: The COVID-19 pandemic has placed immense pressure on the global healthcare sector. The rapid development of vaccines has significantly alleviated the rampant spread of the COVID-19 virus. This research paper aims to determine the success rates of various types of vaccines in preventing COVID. It will first list the brand of the vaccine, then identify the type of vaccine, and describe how the vaccine functions in providing the body immunity from the coronavirus, and finally it will compare the … Read More

Single-Cell RNA Sequencing: A Deep Dive into The Cellular Landscape and Interactions in Osteosarcoma

Sihan Zheng

pp.114-121 DOI: 10.62051/91yqvp26

Abstract: OSTEOSARCOMA is a leading cause of cancer-related deaths worldwide, with its progression highly influenced by the cellular interplay within the tumor microenvironment that is underexplored. Aiming to bridge this gap, our study utilizes single-cell RNA sequencing (scRNA-seq) to examine the cellular heterogeneity of OSTEOSARCOMA and investigate the roles of distinct cell populations. scRNA-seq was performed on eight DEN mice OSTEOSARCOMA samples, followed by bioinformatic analysis with Seurat … Read More

Machine Learning-Assisted Discovery of Novel Anti-HIV Drug Candidates: An Analysis Using Molecular Datasets

Zeyu Gou

pp.122-139 DOI: 10.62051/cfngys46

Abstract: Human Immunodeficiency Virus (HIV) serves as a crisis of global public health, necessitating new anti-HIV agents due to the virus's rapid mutation and subsequent drug resistance. While current Combination Antiretroviral Therapy (CART) has helped control the infection and mortality rates, traditional drug development approaches are costly and inefficient. This study aims to address this issue by applying machine learning algorithms for lead compound discovery using the extensive, quality-assured … Read More

How does CNB-2 act to its surroundings?

Motang Zhu

pp.140-147 DOI: 10.62051/wvbc2d42

Abstract: CNB-2 is a type of unharmful bacteria commonly found in water and dirt areas. It is sometimes used in biological experiments where it is given substances to see if the substance attracts it or not. There are two Typical experiments related to this, which is what will be discussed here. Read More

Research on Endometrial Cancer: Risk factors, Classification and Treatment

Hiu Mei Luk

pp.148-155 DOI: 10.62051/bsnbkf10

Abstract: Endometrial cancer (EC) is one of the most common tumors of the female reproductive system. Its pathogenesis is complex, and the incidence tends to be younger, which seriously endangers women's health. Research has found that the calssification of EC is of great significance in clinical applications, including traditional types I (estrogen-dependent) and II (non-estrogen-dependent), as well as four molecular subtypes (POLE ultramutated, microsatellite instability hypermutated, copy number low, … Read More

Pleomorphic Adenoma of the parotid gland: A Case Report

Nuoya Yang, Wang Zhao

pp.156-158 DOI: 10.62051/7amtxw71

Abstract: Objective: to report a case of left parotid adenocarcinoma in pleomorphic adenoma in order to improve the understanding of the disease. Methods: the clinical characteristics, clinical manifestations and risk factors of a case of left parotid adenocarcinoma in pleomorphic adenoma were analyzed. Results: clinical characteristics: the patient had a long clinical course and was diagnosed as"eft parotid gland cancer in pleomorphic adenoma", in which the cancer component was considered as adenoid … Read More

A Review of Traditional Chinese Medicine Treatments for Pediatric Respiratory Tract Infections

Danyue Shao

pp.159-164 DOI: 10.62051/4j4ygh66

Abstract: The treatment of pediatric respiratory tract infections by traditional Chinese medicine (TCM) methods can comprehensively consider the child’s condition and physical status, and use a variety of methods to comprehensively regulate the child’s condition and achieve better therapeutic effects. The methods used are mainly in acupuncture, herbal medicine, massage, food therapy and emotional conditioning, etc. These methods can be used individually or in combination, and the appropriate treatment … Read More

Synthesis of β-(4-chlorophenyl) lactic acid

Xiling Deng, Xile Liu

pp.165-168 DOI: 10.62051/38vfaq08

Abstract: β-(4-chlorophenyl)lactic acid was synthetized via four steps of reaction, knoevenagel condensation, oxazolone ring-opening, hydrolysis and clemmensen reduction, staring from commercially available compound 4-chlorobenzaldehyde. β-(4-chlorophenyl) lactic acid and its mid-products were identified with 1H NMR, 13C NMR and MS. The spectra and physical constants were concordant with the corresponding structures and properties. The synthetic route we used has the advantages of abundant materials, … Read More

The Diagnostic Value of Stool-Based MicroRNA-135b in the Early Detection of Colorectal Cancer and the Potent Neuro Function of MiR-146a

Juan Peng

pp.169-177 DOI: 10.62051/tdx3ae98

Abstract: Background: Detecting microRNA (miRNA) in stool is a non-invasive approach for colorectal cancer (CRC) screening. This study aims to assess the diagnostic performance of stool-based microRNA-135b in detection of colorectal cancer and the role of miR-146a. Methods: To identify eligible studies that are well suited for diagnostic value of miR-135b in stool of colorectal cancer patients, we have evaluated 3 papers after systematic literature search of public database. The sensitivity and … Read More

Influence of monomer purity on molecular weight of racemic polylactic acid

Xiaoqi Chen, Lu Bai, Fen Zhang, Haijun Zhou, Yao Qian, Yantao Li, Jijun Xiao

pp.178-182 DOI: 10.62051/32ke5t26

Abstract: Aiming at the low molecular weight of polylactic acid due to the presence of water molecules in the ring-opening polymerization of racemic lactide, this paper selected racemic lactide as the main raw material, stannous caprylate as the catalyst, and cetyl alcohol as the initiator, and studied the effects of recrystallization process conditions such as the number of recrystallization and drying time on the purity of monomer. The influence of initiator dosage on the properties of racemic … Read More

Immunoevaluation of hydrophobic modified polyethyleneimine as cationic polymer adjuvant

Lu Bai, Xiaoqi Chen, Chengyu Li, Fen Zhang, Haijun Zhou, Hua Cheng, Yantao Li, Jijun Xiao

pp.183-187 DOI: 10.62051/19x1e293

Abstract: Polyethyleneimine (PEI) is a cationic polymer that has excellent gene transfection effects as a gene transfection reagent. Its excellent proton sponge effect has attracted much attention in the field of vaccine adjuvants. However, its high positive charge density leads to high toxicity, which limits its application. In this paper, polyethyleneimine modified by stearyl chloride was used to reduce toxicity to obtain SA-PEI. The partical size of composite particles formed by SA-PEI adjuvant and … Read More