Zhiyuan Huang
Abstract: Tau is a protein created by alternative splicing of the gene MAPT, which plays an important role in stabilizing the internal structure of neurons. While Tau has been strongly associated with neurodegenerative diseases like Multiple Sclerosis (MS) and Alzheimer's disease, it remains unclear whether Tau is the cause of these diseases or merely a downstream biomarker. To investigate the causal association between MS and Tau levels, a Mendelian randomization (MR) analysis was performed and the …
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Jiatong Shan
Abstract: There are a lot of elderly people who are suffering from decline in cognition or even the dementia like Alzheimer’s disease as they are aging. Although cognitive decline is an irreversible trend for all the human beings, related practitioners can do some interventions to delay this trend. This review summarizes the current interventions to delay the cognitive decline among the elderly people and prevent cognitive diseases like Alzheimer’s among them. The methods mainly include having healthier …
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Tingyi Cui
Abstract: Aging is a multifaceted biological phenomenon influenced by genetic, epigenetic, and environmental factors. Cellular senescence, characterized by an irreversible cell cycle arrest, is a pivotal mechanism contributing to aging and age-related diseases. It is also associated with alterations in DNA methylation, a key epigenetic marker. However, the causal link between senescence-associated DNA methylation changes and aging outcomes remains elusive. In our study, we analyzed three distinct methods …
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Yifei Gao
Abstract: This article introduces the benefits of public health that can be developed related policies through research to prevent or control pandemic or diseases. Cancer is now a major concern of public health worldwide. Research has been conducted to identify and solve the major problems for some types of cancer. This article gives some detailed information for one type of cancer, breast cancer. The third part of the article includes risk factors for breast cancer, which the unhealthy lifestyle is one …
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Litian Chen
Abstract: Heart disease is an international public health issue and a significant health risk for many people. The World Health Organization (WHO) reported that heart disease has been identified as one of the primary causes of death. Owing to its rapid development and application in many areas, Machine Learning has become an effective technique for predicting heart disease. Machine learning, along with large-scale medical data and advanced algorithms, can assist healthcare professionals in accurately …
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Zhiyu Wen
Abstract: Major Depressive Disorder (MDD) is a serious global mental health condition that has gotten worse recently due to its influence on well-being and quality of life. Data from the World Health Organization (WHO) reveal a prevalence of 3.8% for depression globally. Depression's link with various complications necessitates exploring its etiology for effective prevention and management. Insomnia, prevalent in 10-20% of adults, is closely associated with depression. The causal relationship between …
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Yubo Huang
Abstract: Cervical cancer ranks as the fourth leading cause of cancer-related deaths among women and often remains asymptomatic during its initial stages. Therefore, it’s very important to predict it. The study's objective is to explore cervical cancer risk variables and develop an ensemble prediction model to forecast cervical cancer more precisely. The cervical cancer data were represented by 11 risk factors and a dependent variable consisted of Hinselmann, Schiller, Cytology, and Biopsy. SVM, decision …
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Chuanzhe Chen
Abstract: Neurodegenerative disease (ND) represents a chronic disease characterized by loss of neuron function and death, such as Alzheimer's disease, Parkinson's disease, etc. It’s difficult and complex to diagnose ND, due to the requirement for the synthesis of multiple biomarker data, such as genes, proteins, images, etc. The advent of artificial intelligence (AI) technology, particularly through machine learning (ML) and deep learning (DL) algorithms, introduces novel methodologies and tools for ND …
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Kewen Feng
Abstract: People are more willing to have pets in current society. The interaction with pets brings pet attachment to owners. Studies try to find the benefits of the pet; the pet attachment is the measurable variable to evaluate the benefits and function of the pet. The essay discusses the emotional support of pets by dividing it into positive and negative emotional conditions. Each condition introduces two studies to develop the benefits of pets. In the positive emotion condition, the studies show that …
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Yichi Zhang
Abstract: In the course of human history, discussion regarding gender differences and sexual roles has never come to an end. In present-day society, cultural influences, together with the “discovered” physiological differences, have contributed to severe gender inequalities and bias that can be perceived in all aspects. Under this distressing situation, education should be an important aspect that must be paid attention to as it is a determining factor of societal development. Based on empirical research, …
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Zisu Peng
Abstract: Autism, the full name of autism spectrum disorder, is a type of inborn, congenital, or onset in infancy, characterized by social communication difficulties, narrow interests, repetitive stereotyped behaviors, and sensory perception. In recent decades, the incidence of autism has been increasing worldwide. It is estimated that the average prevalence of autism worldwide is about 1%. Therefore, there is no doubt that autism has become a public health issue that has attracted great attention and …
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Xinjie Zhou
Abstract: Exosomes, which are lipid bilayer vesicles actively secreted by cells with a diameter of 30-100 nm, play a crucial role in the occurrence, development, and formation of the tumor microenvironment in breast cancer. They have become an important component of liquid biopsies for breast cancer and ideal targets for early diagnosis, treatment assessment, and clinical therapy. Breast cancer is the most common malignancy among women. However, traditional exosome detection methods have several …
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Zichun Liu, Shuntong Zhang
Abstract: BDNF (brain-derived neurotrophic factor) is a kind of neurotrophic protein, widely distributed in the brain and spinal cord. BDNF is engaged in regulating the growth and migration of neurons, and can promote the repair of damaged neurons. While disorders of BDNF expression can lead to mental diseases such as bipolar disorder. The main way in which the BDNF gene affects bipolar disorder is through BDNF's interaction with TrkB receptors. In addition, BDNF also causes bipolar disorder by affecting …
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Jianning Li, Yunyang Zhang, Ruoyu Zhou
Abstract: Schizophrenia is a challenging mental disorder marked by recurring psychosis. This article provides an in-depth overview of the current status of research and treatment techniques for schizophrenia. The introductory part gives a thorough explanation of the illness, including all of its many phases and symptoms. The review analyzes the genes involved in cell signaling and neurotransmission, including NRG1, DTNBP1, DISC1, and RGS4, which are important contributors to schizophrenia susceptibility. …
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Xinyue Li
Abstract: As a relatively large class of neurological diseases, bipolar has always been an important object of research and exploration by scientists. When bidirectional patients develop the disease, they are aggressive and a great burden for their families. Therefore, how to treat bipolar has been a hot topic. Current treatments for bipolar include medication, psychotherapy, and physiotherapy. Drug therapy includes mood stabilizers, antidepressants, anticonvulsants, antipsychotics and so on. …
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Zhen She
Abstract: The enzyme-linked immunosorbent assay (ELISA) has emerged as an indispensable method in the realm of cancer detection., serving as a significant factor in the timely identification, prediction, and surveillance of many forms of cancer. ELISA as a highly sensitive immunological assay, utilizes the binding affinity between antibodies and antigens to detect and quantify cancer-associated biomolecules, such as tumor markers, oncogenic proteins, and specific antibodies. The recently adopted …
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Zhenkun Chen
Abstract: Ultraviolet-visible (UV-vis) spectroscopy is a spectral measurement technique that relies on Lambert-Beer's law. Due to its user-friendly nature, rapid analytical capabilities, broad applicability, and non-destructive properties, it has gained significant prominence across various scientific disciplines. In the realm of environmental science, UV-vis spectroscopy can be employed for effectively detecting water quality by determining the concentration of heavy metals and related chemicals in water …
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Xingyu Zhou
Abstract: Cervical cancer remains a widespread and challenging malignancy that affects women worldwide and poses significant clinical and public health issues. Since it is difficult to find early cervical lesions in the patient's own state, it is very important to apply appropriate and effective detection and screening for cervical cancer and precancerous lesions. This research investigates the development of cervical cancer and the various subtypes of HPV, which are the primary cause of cervical lesions. …
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Shiying Wu
Abstract: The escalating prevalence of diabetes has emerged as a burgeoning national concern, necessitating comprehensive investigation and intervention. Leveraging data extracted from the 2021 Behavioral Risk Factor Surveillance System (BRFSS), this study harnesses the power of data mining techniques to discern salient variables within expansive datasets. Subsequently, a series of machine learning models, comprising Random Forest, Decision Tree, Lasso Regression, and Neural Network, were constructed, and …
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Haoshuang Wang
Abstract: Globally, depression significantly affecting people's quality of life with a range of negative health outcomes. Previous studies have confirmed a link between BMI and depression. Consequently, this study focused on data spanning from 2017 to March 2020, encompassing individuals aged 18 to 30 years within the National Health and Nutrition Examination Survey (NHANES). The study included 1635 participants, with complete data and selected covariates. Then, used weighted logistic regression models to …
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Luyan Liu
Abstract: Dermatomycosis is a kind of superficial infectious disease of skin, mucous membrane and skin accessory organ, which is caused by fungi. Dermatomycosis is a zoonosis characterized by recurrent, infectious and high morbidity. Nowadays, all studies on the treatment of dermatomycosis in cats and dogs are relatively scattered, so the purpose of this research is to analyze the therapeutic drugs of the dermatomycosis comprehensively by comparing the experimental data and results in other literatures, …
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Fuman Xie
Abstract: Cervical cancer is a very widespread carcinogenic condition that poses a significant threat to women's health. The primary cause of this condition is mostly linked to persistent infection with high-risk strains of human papillomavirus (HPV), which are recognized for their ability to promote the development of cancer. Due to HPV infection, both therapeutic and preventative HPV vaccinations have been developed. Therapeutic vaccines can eradicate viruses and virus-infected cells by stimulating …
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Qinya Liu, Qianyuan Sun, Jiajun Yu
Abstract: At present, the main gene editing tools encompass TREN, Zinc Finger Nucleases (ZFN), clustered regularly interspaced short palindromic repeats (CRISPR), and Transcription Activator-Like Effector Nucleases (TALEN). In this study, we introduce an overview of the three gene editing methodologies and discuss their current clinical applications. In addition, we suggest some trends and future applications within the field of gene editing. ZFNs represent one of the pioneering technologies, …
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Kecheng Liu
Abstract: Breast cancer poses a major threat to the health of women worldwide. This study analyzed data from breast cancer patients to develop a predictive model for identifying cases of the disease that are malignant based on cellular measurements. The dataset from the University of California, included 569 instances of 10 numerical variables such as radius, texture, and concavity of the cell samples. After initially exploring the relationships between the variables, the study used methods such as …
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Chenxi Xie
Abstract: In the past few decades, the diagnosis, prevention, and treatment of BRCA1/2-related cancer, especially breast cancer and ovarian cancer, have been a topic of great concern to scientists and the public. People with mutated BRCA genes are more likely to develop breast and ovarian cancer, and such causes of these types of cancer are inherited. Till now, there is no perfect solution for this gene defect. microRNAs (miRNAs), as important gene expression regulation molecules in humans, are considered …
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Kaijun Yuan
Abstract: RNA interference (RNAi) is a Universal biological system based on double-strand small interference RNA (siRNA). RNAi efficiently inhibit the expression of genes based on a guiding strand. SiRNA can be applied against a broad spectrum of diseases but is limited by insufficient siRNA delivery methods. Delivery of siRNA is a challenging direction of modern molecular biology and pharmacy study; scientists aim to improve the efficiency and accuracy of siRNA-based treatment. Many approaches have been …
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Zhilei Chen, Baichuan Wang, Yishan Yuan, Luhan Zhang
Abstract: Prenatal testing plays a crucial role in addressing the inherent unpredictability of genetic disorders that can affect unborn children. Non-Invasive Prenatal Testing (NIPT) has emerged as a groundbreaking tool in the realm of prenatal care, enabling the early detection of chromosomal abnormalities. By examining fetal DNA present in the mother's bloodstream, NIPT has achieved remarkable accuracy rates, surpassing invasive techniques that carry inherent risks. However, with these advancements come …
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Haowei Li
Abstract: Tuberculosis is classified as a chronic respiratory disease with its pathogen being Mycobacterium tuberculosis (MTB). It poses a significant health threat due to its highly contagious nature and is difficulty in treatment. Various methods are employed to test for tuberculosis, including pathological, immunological and molecular biological tests. Each test has its unique principles and all are different in effects, and are widely used in clinical practice. In this research, principles, …
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Dian Yu
Abstract: In modern society, as artificial intelligence technology becomes increasingly mature, AI can already be utilized to assess and treat breast carcinoma. By summarizing results and data of experiments that use AI to help breast carcinoma diagnosis and cure, this article states the positive impact of AI on breast cancer screening, detection of breast cancer-related genes, and prediction of efficacy of breast cancer treatment drugs. What is more, illustrating the moral, legal, and social challenges …
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Yixiang Sun
Abstract: Prostate cancer (PC) poses significant health risks to men globally. Enhancing our understanding of prostate cancer biology is crucial for facilitating early diagnosis and effective treatment strategies. A multitude of high-throughput sequencing studies, encompassing whole genome resequencing, transcriptome sequencing, and genome-wide association studies, have unearthed vital point mutations, structural variations, and epigenomic alterations linked to prostate cancer. These findings have …
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Leyao Gao
Abstract: The emergence of the CRISPR/Cas9 system has ushered in a new era of genetic editing with vast implications for both therapeutic interventions and drug discovery. This essay explores the extent to which CRISPR/Cas9 elevates target efficiency and revolutionizes drug discovery. While this technology offers unprecedented efficiency, precision, and programmability in genome editing, concerns about off-target effects have arisen. The essay discusses the transformative impact of CRISPR/Cas9 in drug …
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Yuming Liu
Abstract: The prevalent chronic lung condition known as idiopathic pulmonary fibrosis (IPF) is defined with the repeated scarring of pulmonary tissues. About 3 million individuals are impacted globally, and that figure is only increasing. There are no effective treatments available right now to help IPF sufferers with their symptoms. The lungs, one of the essential organs in charge of exchanging oxygen, are affected by lung cancer, a terrible condition that can be fatal. It affects both men and women of …
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Jinqi Guo, Haibin Hu
Abstract: With the continuous advancement of medical technology, glucagon has been confirmed to be closely related to many diseases, such as diabetes, glucagonoma cell hyperplasia and neoplasm (GCHN), hepatitis and neurological diseases, which take numerous life each year. The identification of several diseases, like Mahvash syndrome as an autosomal recessive inherited pancreatic neuroendocrine tumor syndrome associated with GCGR inactivation mutations deepens our understanding of GCG signal pathway. As …
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Shuyang Liu
Abstract: As the level of modern medical treatment gradually advances and improves with the development, therapeutic vaccines are gradually being researched and applied in clinical treatment, but there are still some areas that require further research and improvement. This article summarizes the research progress, market development, awareness and popularity of cervical cancer therapeutic vaccines in recent years and treatment scope. The study found that the clinical basis for therapeutic vaccines and …
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Yiwei Li
Abstract: Diabetes is a disease that is increasingly prevalent on a global scale. Type 2 diabetes (T2D) accounts for 90% of all diabetes cases and is a chronic condition primarily influenced by factors such as obesity and genetics. This condition often leads to the development of various cardiovascular diseases. A diverse of different detection methods for the T2D have been developed and achieved good detection and analysis results. In addition, numerous studies have indicated a close connection between …
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Yiyan Lin
Abstract: This paper discussed the recent studies on the behavioral and neural patterns of individuals with depression and those with familial risk in reward-based decision-making. Current theories for depression and reward-based decision-making were presented so that they can pave the way for investigation of the interaction between the two under scrutiny. The paper argues that depression influences individuals’ aspects of reward-based decision-making, including thinking strategies, flexibility, reward …
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Duoxiang Zhao
Abstract: Autism Spectrum Disorder (ASD) is a multifaceted neurodevelopmental condition that predominantly affects males and manifests through diverse behavioral impairments, such as difficulties in social engagement and a tendency towards limited, recurrent behaviors. Concepts like the theory of mind and the executive function theory notably emphasize the underlying aspects of the condition, highlighting deficits in understanding others' mental states and domain-general cognitive difficulties, …
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Taisen Zhang
Abstract: This research discusses the mechanisms of current medical treatments for breast cancer and a brief analysis of the treatments. The aim of this research is to present the different cancer therapies and to select the most promising and promising therapies for breast cancer based on the performance of each therapy, where chemotherapy, radiotherapy, and immunotherapy for breast cancer are discussed. By analyzing the various therapies, it is concluded that all three therapies selected for discussion …
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Fengyu Bao
Abstract: Multiple sclerosis (MS), one of the most prevalent autoimmune diseases, poses a significant challenge for therapeutic advancements. Among these, antigen-specific therapies (ASTs) utilizing therapeutic vaccines have emerged as highly promising. Designed to induce antigen-specific tolerance without compromising the overall immune system, these vaccines offer a glimmer of hope for MS patients, despite many still being in the preclinical trial phase. This research provides an elaborate comparison of …
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Zeyue Li
Abstract: Non-small cell lung cancer, also called NSCLC, makes up 85% incidence in lung cancer, presents a considerable challenge for its high mortality rate and poor prognosis. In recent years, the invention of programmed cell death 1 (PD-1) inhibitor nivolumab, which is a type of immune checkpoint inhibitors, emerging as a groundbreaking drug, has offered a potential solution to tackle the inescapable drawbacks of traditional cancer treatments. Several clinical trials assessing nivolumab's efficacy and …
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Yifang Li
Abstract: Due to the prevalence and severity of Major Depressive Disorder (MDD), it is essential to examine the effectiveness of Mindfulness-Based Cognitive Therapy (MBCT) when treating and preventing the recurrence of MDD. This paper evaluated recent research in this area. First, this article described the importance of research on MDD, which has led to considering MBCT techniques for treating MDD. In addition, this article presented previous literature which explored the symptoms and causes of MDD, as …
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Juan Fu
Abstract: Light is full of the world and illuminates our lives, and scientists believe that light must play a crucial role in affecting humans either positively or negatively including circadian functions and emotion-related behaviors. Through experiments, researchers have revealed the fact that light can affect humans significantly and the principles behind phenomena of light influencing humans both physically and mentally. This essay focuses on how light works in humans’ circadian rhythm and mood …
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Xi He
Abstract: Photodynamic therapy (PDT) is one of the developing treatment modalities that has been clinically approved for cancer treatment. It uses an organic photosensitizer that harnesses the light energy and converts intracellular oxygens to reactive cytotoxic species. The resulting chemicals can then damage cells and lead to cancer cell death. However, the existing photosensitizers do not show cancel cell or organelle specificity, which lowers their treatment outcomes. In this project, we used …
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Shangyang Liu
Abstract: CRISPR (short for Clustered Regularly Interspaced Short Palindromic Repeats) and the accompanying endonuclease Cas9 are potent tools for gene editing in many applied disciplines. The CRISPR/Cas9 system primarily functions through two components, in which the single guide RNA (sgRNA) directs the Cas9 protein with endonuclease activity to carry out precise DNA cleavage. The cell's inherent repair mechanisms allow it to complete the subsequent reconnection of the broken genes. Gene knock-in or …
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Shixing Yuan
Abstract: The biological and clinical fields have recognized the CRISPR/Cas9 (clustered regularly interspaced short palindromic repeat/CRISPR associated protein 9) system as a precise and efficient tool for editing the genome. Despite its merits, the system poses crucial challenges, notably the off-target effects which could lead to unintended mutations - a substantial impediment for clinical applications that may potentially compromise the validity of research and the safety of therapeutic applications. …
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Yiyi Zhong
Abstract: Cancer is a main reason of death worldwide, there was about 10million deaths caused by cancer in 2020. Radiotherapy, as a traditional method of treating cancer, uses radiation to kill the lesions of tumor patients. People develop radiation sensitizers to improve the treatment efficiency of radiotherapy and achieve better therapeutic effects through multiple collaborative treatments. Because nanomaterials have special physical and chemical properties, they may bring us novel methods to increase …
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Mengxue Zhang
Abstract: A brand-new coronavirus dubbed COVID-19 epidemic broke out in the winter of 2019 and quickly swept the globe. Additionally, the pandemic's high mortality rate and high infection have prompted sustained scientific efforts to treat the illness. Backing the history of the virus, vaccine development is the most effective method to mitigate this urgent public issue. Pharmaceutical firms from nations including China, the United States, and Russia subsequently started doing research on vaccine …
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Yuheng Wu
Abstract: Art therapy (AT) is a method of treating psychological illnesses and improving mental health that uses artistic means. Depression is a medical condition that could cause changes in one's feelings, thoughts, and behaviors. This paper focuses on testing the effectiveness of art therapy on depressive symptoms with its relevant factors by analyzing the most recent research progress in this field. With the evaluation of the paper, it can be concluded that depression symptoms can be reduced by art …
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Zhiling Liang
Abstract: Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental condition that profoundly disrupts a child's capacity to maintain focus, impacting various aspects of their daily existence. This article delves into the intricate realm of compromised sustained attention in children diagnosed with ADHD, offering an exhaustive examination of the contributing factors and their clinical implications. Employing extensive research, this research delves into the multifaceted facets of attention …
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Xi Yin
Abstract: Depression and sleep difficulties have a strong association. Depression may coexist with long-term sleep difficulties in some people, and vice versa for those who already have depression, they are more likely to develop sleep disturbance. In other words, the development of one symptom can trigger the development of another. Patients must therefore pay close attention to their sleep difficulties. Numerous psychiatric illnesses that are related to sleep difficulties might worsen a patient's …
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Jiaer Ye
Abstract: As the world population ages, Alzheimer’s disease (AD) has emerged as a significant public health issue. The regulatory measures, clinical strategies, and even the scientific communications regarding AD all rely on the advancements in uncovering AD pathology, and the ability to recapitulate the disease-relevant players in a “gestalt” and clinically-applicable manner. Neurologists have sought to post mortem validation of AD pathologies (amyloid plaques and neurofibrillary tangles) in brain …
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Xiaoyang Zhou
Abstract: The early detection of cancer is crucial in improving treatment success rates and survival rates. The primary focus of this research is the application of enzyme-linked immunosorbent assay (ELISA) in early cancer detection, as well as the measurement methods of cancer biomarkers. It can provide an overview of the currently used cancer biomarkers and their application in ELISA. Furthermore, this research will utilize the ELISA technique to determine whether a specific substance can serve as a …
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Yanxin Hu
Abstract: P53 is capable of controlling cell proliferation, senescence and apoptosis, as well as DNA repair through regulation associated genes expression. Nearly 50% of human malignancies harbor mutations in TP53 gene, which were identified as a common feature of many cancers, often leading to the accumulation of abnormal cells and uncontrolled cell growth. Research into therapeutic strategies targeting mutp53 began nearly 20 years ago. However, few drugs have entered clinical trials, and with the …
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Yehao Li
Abstract: Kidney cancer has been a concern by society for many years because the pathogenesis of kidney cancer is complex, it may be related to genetic factors, environmental factors and lifestyle. Early diagnosis is crucial for the treatment and prognosis of kidney cancer, but there are still certain challenges. Advances in kidney cancer include gene mutation research, immunotherapy, targeted therapy and liquid biopsy. These research advances are expected to provide more accurate and effective methods …
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Zhijie Yao
Abstract: Cancer poses a significant threat to human health. It is a kind of complex and severe diseases characterized by the expanding of abnormal cells in the whole body due to uncontrolled growth. If left untreated, cancer with metastasis can invade nearby tissues, spread to other parts of the body, and impair the normal functioning of organs and systems. There are some treatment methods for it, such as surgery, chemical therapy and radiation. The field of immunology has made tremendous strides in …
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Wen Cao
Abstract: Immunotherapy has become a well-known cancer treatment method recently. The expeditious development of COVID-19 vaccines has made the extensive use of messenger RNA (mRNA) vaccines possible, and strikingly increased research data have been devoted to exploiting the potential of mRNA vaccines as preclinical and clinical treatments for cancer. mRNA cancer vaccines can stimulate durable and targeted immune responses against tumor antigens (TAs). Despite the promising future of mRNA vaccines, some …
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Zhenning Min
Abstract: Non-small cell lung cancer (NSCLC) is the major type of lung cancer, accounting for 85%. The common options for treatment include surgery, radiotherapy, chemotherapy, immunotherapy, and molecularly targeted therapy depending on the stage, histology, genetic changes, and health condition of patients. Sadly, just 15% of individuals with stage III NSCLC are still alive after five years, which indicates a bad outlook. Because of the use of PD-1 and CTLA-4 immune checkpoint inhibitors (ICIs), …
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Di Zhao
Abstract: Over 18.1 million patients worldwide affected by more than 100 different types of cancer. Cancer is one of the critical focuses of medical research today. Researchers have discovered numerous types of cancer, with many patients and a lack of effective unified treatment methods. Therefore, it is urgent to study the pathogenesis and treatment methods. Proteogenomic is an interdisciplinary field focusing on genomics, transcriptomics, and proteomics, which has shown significant effectiveness in …
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Gang Zhao
Abstract: Background: Non-muscle-invasive bladder cancer accounts for the 75% of bladder cancers but with limited kinds of therapies, especially in the situation that the shortage and high failure rate of intravesical bacillus Calmette-Guérin. There is some evidence that hyperthermic intravesical chemotherapy could enhance the effect of normal intravesical chemotherapy and may be the alternative. Method: To verify the effect of hyperthermic intravesical chemotherapy, we searched three databases including …
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Guanchong Chen
Abstract: Nisin is a classical bacteriocin consisting of thirty-four amino acid residues and undergoing a high degree of post-translational modification to form a unique pentacyclic structure. Nisin is mainly synthesised by lactic acid bacteria. Under natural conditions, it exhibits strong antibacterial activity against Gram-positive organisms and, when combined with chelating agents, is effective against Gram-negative organisms. An excellent safety profile, low cytotoxicity and slow development of …
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Ruiyang Xu
Abstract: This study presents the benefits of Bifidobacterium longum in countering the negative effects of antibiotics, caesarean delivery, and formula feeding on infant gut microbiota. Antibiotics, often used post-caesarean to prevent infections, can impede the development of neonatal microbiota, reducing bacterial diversity and altering gut structure. The microbiota of caesarean-delivered infants exhibits less diversity, a problem that can be mitigated by probiotic supplementation. Breastfeeding, rich …
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Lingfei Li
Abstract: The starter culture of traditional steamed buns is composed of a variety of microorganisms, among which lactic acid bacteria are the main source of fermentation. The quality of the product is directly affected by the diversity and abundance of lactic acid bacteria. As a probiotic that plays an important role in many fields, lactic acid bacteria have an important impact on the quality of steamed buns. These effects include enhanced nutritional value, improved flavor, altered texture, extended …
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Yiming Fan
Abstract: Adeno-associated virus (AAV) has proven highly effective as a delivery vector in clinical trials for gene therapy. The safety and efficacy of AAV have led to its application as a novel approach for cancer treatment. Many successful clinical trials of cancer have demonstrated the feasibility of this approach. This review mainly introduces the structure, characteristics and application of AAV in tumor models. The promise of gene therapy in addressing diverse diseases has become evident, with AAV …
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Yuxi Li, Yuzhi Liu, Guanyu Lu
Abstract: Kidney diseases, particularly chronic kidney disease (CKD), represent a significant health concern, particularly as one ages. This paper delves into an in-depth analysis of CKD, exploring its prevalence, risk factors, and the complex interplay of conventional and nontraditional determinants. Notably, socioeconomic, genetic, and lifestyle factors are pivotal in understanding CKD's multifaceted etiology. The research employs a diverse dataset from Bangladesh, applying statistical techniques …
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Miaoshu Wang
Abstract: The physical fitness improving capacity of probiotics has been proved to be valid but easy to degrade when exposed to the environment of processing, storage, and human gastrointestinal tract. A series of research have shown that the microcapsule embedding technology or coating technology with certain Maillard Reaction products (MRPs) as the wall material has the potential to improve the delivery condition, protect the probiotic supplements and helping the ideal expressing of probiotics in the …
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Yichen Guan
Abstract: Probiotics are a kind of active microorganisms that are beneficial to the host by colonizing in the human body and changing the composition of the flora in a certain part of the host. The organic acids, special enzymes and actinomycin’s produced by lactic acid bacteria (LAB) have special physiological functions. LAB can regulate the normal flora of gastrointestinal tract and maintain the microecological balance, so as to improve gastrointestinal function, increase food digestibility and …
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Yunan Zhang
Abstract: A two-pronged approach to fighting cancer, oncolytic virotherapy (OV) combines direct tumor cytotoxicity with potentiation of anti-tumor immunity. Combining OVs and cell therapies, such as CAR-T and NK cells, has been proposed as an enhanced therapeutic approach. Additionally, it has been demonstrated that adding oncolytic virotherapy to combination medicines increases their therapeutic potential. This article explains the mechanisms underlying oncolytic viruses, the beneficial interactions …
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Sijie Yin
Abstract: Numerous studies have demonstrated that the ability of protecting malignant cells from immune destruction—particularly from T and B lymphocytes, macrophages, and natural killer cells—is linked to the aetiology of cancer. Malignant cells hold the capacity to activate specific immunological checkpoint pathways that have immunodepressant qualities, which is why immunosuppression is connected to the growth and spread of cancer. Immunotherapy has grown to be a crucial method of therapy for cancer. …
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Wenrui Zhao
Abstract: CITE-seq consists of mRNA sequencing and labeled antibody sequencing. This paper predicts labeled antibody sequences based on LSTM neural network. Research shows that LSTM algorithm has a reliable application in CITE-seq protein expression prediction technology, and the prediction accuracy rate reaches 95%. The LSTM algorithm proposed in this paper is relatively accurate and can simulate the gene sequence of proteins well. The CITE-seq data training model learns the potential relationship …
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Xinyue Xu
Abstract: Tea has been a beloved beverage for centuries, enjoyed by people all over the world. Tea polyphenols, natural bioactive compounds abundant in tea, have gained increasing attention for their potential health-promoting properties. This study provides a comprehensive overview of the multifaceted interactions between tea polyphenols and gut microbiota, shedding light on their roles in health and disease prevention. The opening section provides an in-depth examination of the definition and …
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Liqiao Zhu, Yifeng Peng, Lancong Xie, Yiwen Chen
Abstract: To understand the spread of COVID-19, the data sets from Google and GitHub are obtained by using Python and R, and ARIMA model is established for prediction. By visualising the data sets, it can be found that the total trend of the COVID-19 is bimodal and reaches its peaks during the winter and spring time in 2022 and 2023, and this may due to the virus activity and government management. When taking into prediction, ARIMA (3,1,3) is the best predict model to forecast the overall spread trend of …
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Haoyue Jia
Abstract: BRCA1 and BRCA2 are vital tumor-suppressed genes closely related to the presence of ovarian cancer. Recent bioinformatic approach has been applied for identifying the potential carrier of BRCA mutant via miRNA microarray expression. However, our statistical analysis suggests that the limma filter method may not reflect true genotype status despite the significance some data render. In order to refine the identification of the BRCA subtype through differentially expressed miRNAs, the rank sum …
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Xiaoyuan Liu
Abstract: The T cellular immune receptor with immunoglobulin and TIGIT, an immunoreceptor tyrosine-based inhibitory motif, is a recently identified immune checkpoint molecule primarily found on the outer membrane of T cells and natural killer (NK) cells. It is mediated by binding to ligands such as CD155 inhibits T and NK cells' Immune response and influences of tumor microenvironment. At present, many studies have identified the main pathway and mechanism of TIGIT control, and some drug companies have …
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Haoyu Sun
Abstract: CRISPR-Cas9, composed of Clustered Regularly Interspaced Short Palindromic Repeats and CRISPR-associated protein 9, is a pivotal tool for precise genetic manipulation with diverse biomedical applications. In this system, the scientists use single guide RNA (sgRNA) synthesized from tracrRNA and crRNA to lead the Cas9 protein to target specific gene locations, thereby achieving gene editing. Nonetheless, drawbacks like single guide RNA's limited efficiency led to frequent base mismatch and …
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Junyan Zhang
Abstract: Covid-19 has spread worldwide, with its initial outbreak occurring in China. The Chinese government employed not only Western medicine but also traditional Chinese medicine (TCM) in their response. TCM, due to its potential to enhance human immunity, was considered a valuable tool in prevention. Furthermore, the analysis of TCM recipes has shed light on their efficacy. Some of the five recipes, including LHQW, XFBD and LCDD, have been found to have the capacity to enhance the patients’ immunity …
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Keming Liu
Abstract: An overview is presented in this review, which delves into the neural pathways associated with anxiety disorders. The emphasis is placed on the amygdala and prefrontal cortex circuit, the GABAergic pathway, and the serotonin pathway. The amygdala-prefrontal cortex circuit is essential to processing fear and making decisions; anxiety disorders have been linked to disruption in this circuit. The GABAergic pathway, characterized by the release of GABA and inhibition of neuronal activity, is …
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Haolun Han
Abstract: In the realm of sports, fitness, and physical activities, shin splints are closely connected with athletes, runners, and ballers. The discomfort and pain associated with the athlete spirit bring about the worst feeling when facing challenges in recovery. This essay delves deep into the area of shin splints, pointing out the intricate web of factors that contribute to the development and impact on individuals who are working on and trying to overcome the pain. Besides, the review Includes more …
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Yichen Li
Abstract: Immune checkpoint inhibitor (ICI) is a new type of tumor treatment drug, also known as immunotherapy drug. They target "checkpoint" molecules in the body's immune system that prevent immune cells from attacking cancer cells. They target "checkpoint" molecules in the body's immune system that prevent immune cells from attacking cancer cells. The use of immune checkpoint inhibitors can help control or treat certain types of cancer by promoting the restoration of inactivated immune cells and …
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Runfei Miao
Abstract: In this comprehensive review, we delve into the transformative impact of bioinformatics in cervical cancer research, emphasizing its role in shifting from traditional clinical and pathological approaches to a nuanced molecular and genetic understanding. We explore the evolution of cervical cancer research, highlighting the pivotal transition marked by the identification of human papillomavirus (HPV) and the subsequent advancements in screening and vaccination. Central to this review is the …
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Tiancheng Xu
Abstract: Gastric cancer is one of the biggest medical problems in the world today, and it is also a huge medical challenge for human beings. The main challenge is the complexity of the limitations of gastric cancer itself. At present, the efficacy of single-drug immune checkpoint inhibitors in treatment is not clear. It can be found in previous cases that Epstein-Barr virus positive gastric cancer patients have significantly higher response to PD-1 antibodies than the overall patients, from which it can …
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Yiwen Chen
Abstract: In the immune microenvironment, the sugar metabolism of tumor cells determines their own growth, and the disturbance of metabolic process is considered as an important feature of tumor cell growth. Compared with normal cells, the greatest change in the metabolic process of tumor cells is the occurrence of aerobic glycolysis. Even under sufficient oxygen conditions, tumor cells will still absorb a lot of glucose through glycolysis to provide energy for cells, and many important rate-limiting …
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Caiwei Wang
Abstract: The use of immunotherapy as a treatment modality in the field of cancer has garnered significant attention since its discovery. Among these, studies have demonstrated the substantial benefits of using programmed death 1 (PD1)/programmed death ligand 1 (PD-L1) inhibitors in the treatment of non-small cell lung cancer (NSCLC). However, as research continues, there are differing advantages and disadvantages to this treatment for NSCLC. Adverse effects related to the immune system and high costs are …
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Xinyu Fan, Zhiqi Zhu, Ziyi Zhao
Abstract: Initially, it was believed that the unfolded protein response (UPR) was a network signal that synchronized apoptotic and adaptive responses to the buildup of unfolded proteins in the endoplasmic reticulum (ER). The endoplasmic reticulum stress sensor IRE1 is a major player in the UPR, and overactivation of IRE1 can promote a variety of pathological phenomena, such as diabetes, neurodegenerative diseases, and cancer. Under endoplasmic reticulum stress, IRE1 is activated through …
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Shenghan Gao, Xuru Miao, Jiaqi Liu
Abstract: The CRISPR/Cas system is a natural immune mechanism present in prokaryotes, which protects itself by specifically cutting off viral DNA that invades the bacterial body. Under the research of scientists, CRISPR technology has developed into a powerful tool in tumor immunotherapy. It can reduce the inhibitory effect of tumor microenvironment on T cells and enhance tumor immunity by specifically knocking out genes at immune checkpoints (such as PD-1/CTLA-4) on T cells cultured in vitro. However, …
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Junshuai Zhu
Abstract: The shoulder joint is a flexible but unstable joint in the human body. Also, it has complex structures including coracoacromial arch, synovial bursa, head of femur and so on. Based on these traits, shoulder joints have a wide range of activity, but some lesions accompany with, especially some overhand motions like throwing baseball, swimming, lifting the weight above head repetitively. Diversification of pathogenic factors are significant traits of this kind of injury. In addition, lesions of …
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Yuchen Song
Abstract: Plantar fasciitis is a frequent, chronic ailment that significantly affects day-to-day functioning. This review takes a deep look at the different therapies and preventions used in the treatment of this condition to improve foot function, reduce pain, and improve patient outcomes. The efficacy of common treatment options such as physical therapy, medication, stretching, night splints, therapeutic ultrasound, and extracorporeal shock wave therapy has been mentioned again in this study. Moreover, …
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Huiyang Yu
Abstract: The illness known as intervertebral disc degeneration (IDD) is characterized by discomfort in the intervertebral discs. The IDD is made up of the annulus fibrosus (AF) and nucleus pulposus (NP), which function as a joint and cushion for the spine. IDD can develop with ageing, which can cause the NP to herniate and cause pain. IDD patients experience detrimental effects on their quality of life and mental health in addition to their physical health. It also poses a critical economic burden on …
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Jingru Xu
Abstract: Optical coherence tomography (OCT), which uses light wave as the imaging method, is a new medical imaging technology based on optical coherence. Optical coherence tomography angiography (OCTA) is a non-invasive imaging method gradually emerging in recent years. This technique can detect flowing blood and evaluate tissue morphology by detecting normal flow of red blood cells in blood vessels. Because of the advantages of high resolution, easy operation and three-dimensional imaging, it is widely …
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Yichen Li
Abstract: A torn meniscus, a prevalent knee injury, holds significant importance due to its impact on post-surgery outcomes. Failure to undergo timely and appropriate rehabilitation can result in numerous complications, including muscle atrophy and limited joint mobility. Current research has made strides in assessing the efficacy of various rehabilitation protocols for patients with meniscus tears, aiming to restore strength and functionality to the affected knee. Despite progress, challenges persist, …
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Tingxi Luo
Abstract: This systematic review provides a comprehensive analysis of Alzheimer’s Disease (AD) pathology and its pharmacological advancements. Population aging over last decades render AD becoming more prevalent, indicating a significant sociological and economic burden. Yet, due to the complexity of the brain structure, the researchers must understand AD’s multifactorial pathology and progression mechanisms in order to find an effective treatment. The review will primarily examine the classical amyloid-β …
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Zhenglu Zhang
Abstract: Stroke is one of the major causes of death and disability worldwide. Proper diet is an important primary prevention strategy in the long-term management of cerebrovascular diseases. The currently popular MD, DASH, MIND, and Japanese dietary patterns all have significant significance in research on the prevention and treatment of cerebrovascular diseases. Due to the vast geographical area and dietary differences, there is currently a lack of comprehensive epidemiological research on dietary …
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Jie Zhang, Yuting Huang, Yezhi Yuan, Pei Fan, LIangyu Li, Yi Qin
Abstract: The research team backtracked the gastrointestinal electron microscopy manifestations of patients based on the pathological classification of clinical institutions. Through data backtracking, we obtained the diagnostic significance images of the patients. The diagnostic significance images were classified and implemented using convolutional neural networks, with Class A being benign lesions, Class C being malignant lesions, and Class B being non lesions. Based on existing data, we obtained a …
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Linyan Li, Hao Chen, Enquan Shi, Han Wang, Jingyue Wang, Yixian Lin, Tao Yu, Yaxi Huang, Han Dan, Chenchen Wang, Qin Yi
Abstract: With the support of the Institute of Cancer Hospital of Chifeng University, Sarkov and Markov Memorial Health Informatics Laboratory designed a new working concept of innovative Nursing by using neural network and Brain–computer interface technology. The research team proposed a direct connection between human or animal brain (or brain cell culture) and external equipment. In the case of one-way Brain–computer interface, the computer may accept commands from the brain. Using this point to detect …
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Xiaorui Guo
Abstract: Cancer has become an obvious health problem and scientists focus on this to help the problem. Antibody drug conjugates (ADC) has been considered as an efficient way to treat cancer. There are already many ways to produce ADC, but traditional methods need long and complicated biochemical process. Synthesis methods with high efficiency need to be found. This article aimed to describe three new methods for ADC synthesis, and it came out that all these three methods have high quality and can be used …
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Yan Yan
Abstract: Cervical cancer, associated with human papillomavirus (HPV), is currently the fourth most prevalent cancer among women in the world. Though nowadays there are HPV vaccines available on the market, more strategies need to be taken to improve them and develop more therapeutic vaccines. Recent research has mostly concentrated on the state of HPV vaccinations, including their mechanisms, clinical efficacy, and room for improvement. However, there is a significant research deficit in the field of …
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Siyuan Qian
Abstract: Cancer drug resistance is one of the reasons why cancer remains one of the deadliest diseases. Many drugs show initial efficacy in treatment but fail to exert their effects due to various mechanisms, which is particularly evident in immunotherapy. Currently, research is ongoing on anti-resistance drugs that target immune suppression, mutations, and the tumor microenvironment (TME). However, the current immunotherapy approaches have not yielded satisfactory results, with most patients developing …
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Sheng Xu
Abstract: Acute Myeloid Leukemia (AML) is an aggressive hematologic malignancy, presenting a significant challenge in the field of medicine. In this context, Hematopoietic Stem Cell Transplantation (HSCT) has garnered widespread attention as a potential therapeutic approach. This paper reviews the current research progress in the field of AML treatment, with a specific focus on the application of HSCT. Through a comprehensive analysis of recent literature and clinical trials, it systematically summarizes …
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Jiayi Wang, Kaixin Wang
Abstract: One ground-breaking novel treatment that is being utilized extensively in the field of cancer treatment is chimeric antigen receptor (CAR)-T cell therapy. Three axes are used by CAR-T cells to promote tumor killing: Targeting the antigen-positive fraction is the Perforin and Granzyme axis; Targeting the antigen-negative fraction is the Fas and FasL axis; and Cytokine release is focused on the Stromal cell. As a result of this technology's widespread use, its benefits and applications have …
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Tianyi Zou
Abstract: Chimeric antigen receptor (CAR)-T cell therapy is a revolutionary new therapy. Since its first discovery, CAR-T therapy has become the fastest growing and most widely used branch of anti-cancer immunotherapy. The field of hematological malignancies has undergone a rapid transformation due to the advent of this technology, which is responsible for over 50% of all cell therapies that are being developed or sold nowadays. With the extensive use of CAR-T cell technologies, more and more advantages …
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Mingrui Li
Abstract: The complexity of cancer as a global health problem has also led to the development of various novel therapeutics, including prophylactic vaccines. Scientific breakthroughs and technological developments have changed cancer research; since cancer is a complicated disease with many factors, more and better vaccines are required. The research stresses the worldwide influence of cancer and modern therapeutic approaches, such as vaccination. With advances in molecular and cellular biology, cancer …
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Zhaoyang Jiang
Abstract: Extracellular vehicles (EVs) are small lipid vesicles that can release signaling substances containing proteins, nucleic acids, and other bioactive molecules. Recent research shows that EVs have potential application prospects in the treatment of cardiovascular diseases. EVs can alter the function of damaged cells and promote the repair and regeneration of cardiovascular tissue by transmitting bioactive molecules. In addition, EVs have the characteristics of low immunogenicity and high …
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Yuwei Xiong, Xiaoyi Feng, Feiran Gao
Abstract: This paper discusses the prediction model of hematoma expansion probability in patients with hemorrhagic stroke. Hemorrhagic stroke is an acute and critical neurological disease. High mortality and disability make it a major challenge in the field of public health. Hematoma dilatation and peri-hematoma edema are important factors leading to secondary brain injury. therefore, accurate prediction of the risk of hematoma expansion in patients with hemorrhagic stroke has important guiding …
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Fusheng Luo
Abstract: Cancer is one of the most fatal contributors towards the increasing mortality rate of mankind. This represents an important topic to study for the sake of the welfare of humanity. However, the traditional manual diagnosis and prognosis procedures of this disease are quite time-consuming, even for a professional medical practitioner. Thus, a model with robust power of predictions regarding the state of the tumour (i.e., probable cancer) would benefit most patients from the toxic side effects and …
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Mingjun Wang
Abstract: Alzheimer's disease (AD) is a progressively worsening neurodegenerative disorder, where early diagnosis is crucial for implementing effective disease management strategies. In multimodal diagnostic pathways, Magnetic Resonance Imaging (MRI) plays a pivotal role as a non-invasive imaging technique in disease identification and progression monitoring. Deep learning, particularly Convolutional Neural Networks (CNN), can extract key biomarkers from complex imaging data. By training CNN models to …
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Mingyu Ouyang
Abstract: In today's world, breast cancer has become the most common malignant tumor, so this paper mainly classifies the features of breast cancer through BP neural network to improve the accuracy of research and judgment. This paper mainly adopts 30 breast cancer feature data of 569 cases, and then obtains the feature data used in this BP neural network through correlation analysis, feature selection and principal component analysis. By training, the BP neural network that is most suitable for this data …
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Yu Yuan, Xingchi Chen, Qirui Zhang, Ruihan Xu, Jing Jiang
Abstract: Chaperone Service are designed to save time and effort by assisting patients with hospital visits, including registration, queuing, and billing. This article summarises the theoretical foundations of the professional escort field, developments, the definition of the concept of the escort service industry, the concept of the escort, the distinction between the escort and the traditional care worker and the "ticket scalper" robbing the number on behalf of the patient, as well as the demand for …
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Rongli Tang
Abstract: In recent years, with the continuous innovation of medical devices encouraged by the government and the investment and attention of enterprises in research and development, coupled with the relevant requirements of the CDE (Center for Drug Evaluation) of the National Medical Products Administration, in order to improve the efficiency of trials and accelerate the launch of cholangiography robots, medical device research and development enterprises are increasingly focusing on the design of …
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YuNing DU, EnLong Wang
Abstract: The widespread epidemic of Coronavirus disease 2019 (COVID-19) worldwide has had a tremendous impact on both human life and health. The mechanism and treatment of the post-COVID symptoms after acute infection in patients with the COVID-19 has become an important research content at present. Insomnia is one of the most common sequelae after COVID-19. Modern medicine believes that the pathogenesis of insomnia after COVID-19 is related to psychological factors, persistent inflammatory reaction and …
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Yitong Zhao, Xiuting Bai, Xueman Zhang, Mengyu Zhang
Abstract: With the increasingly in-depth marine research, the high-value utilization of seafood has been a research trend, among which the research on microalgae polysaccharides is sufficient. At present, a large number of studies have shown that microalgae polysaccharides have a wide range of biological activities, but their structural analysis is not systematic. Thus, in the past, the research on microalgae polysaccharides mostly focused on a single dimension. In this paper, the structure, composition, …
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Yeru Zhang
Abstract: With the development of nuclear power, the removal of radionuclides is an important responsibility and task. Radioactive iodine, as one of the most radionuclide in nuclear wastes, its safe disposal is essential to ensure the sustainable development of the nuclear industry. Covalent organic framework materials are crystalline organic porous materials, which were constructed by covalent bonds. Because of their regular pore structure, large surface area and high chemical stability, covalent organic …
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