Abstract: The protein tyrosine phosphatase, PTPN11, exerts a crucial inhibitory influence on the MAPK/ERK signaling cascade. This research endeavored to unravel the involvement of PTPN11 in the initiation and progression of glioma, as well as its underlying molecular interactions. To achieve this, Western blotting was employed to observe alterations in ERK phosphorylation upon PTPN11 depletion or amplification. Furthermore, immunoprecipitation coupled with mass spectrometry was utilized to pinpoint the … Read More

Abstract: Digital technology plays an increasingly important role in the display of paleontological skeletal specimens. Through technologies such as high-precision scanning and virtual reality, viewers can immerse themselves in the living environment of ancient organisms and experience unprecedented interaction. In this process, there are also technical challenges, such as the fragility of specimens, the balance between scientific and educational display content, and so on. In order to fully leverage the … Read More

Abstract: In this study, the strategy of enhancing immunogenicity of genetically engineered vaccine and its application potential in tumor treatment were discussed. Firstly, the study explained the principle that genetic engineering vaccine designed antigen by gene recombination technology to trigger strong immune response. By adjusting gene combination, improving vaccine delivery system and using adjuvant, the immune stimulation ability and delivery efficiency of vaccine were improved. Especially in … Read More

Abstract: Introduction: it constructed recombinant DNA vaccine of extracellular region of vascular endothelial growth factor receptor 2 (VEGFR2) and analyzed its in vivo activity against H22 transplanted hepatoma. Methods: the gene fragment of VEGFR2 extracellular region 1-3 was amplified, and the pcDNA3.1(+)/exVEGFR2 recombinant plasmid was constructed. The expression of exVEGFR2 was detected by Western blot. Subsequently, liposome (LP) pcDNA3.1(+)/exVEGFR2 complex (LP-pcDNA3.1(+)/exVEGFR2) was prepared … Read More

Abstract: Cancer Stem Cells (CSCs), as a unique subset of tumor cells, play a crucial role in tumor initiation, progression, and recurrence due to their self-renewal and differentiation capabilities. CSCs exhibit significant immune evasion abilities, allowing them to escape host immune surveillance, leading to the failure of conventional treatments. This paper reviews the definition, characteristics, and immune evasion mechanisms of CSCs, including immune checkpoint pathways, immunosuppressive … Read More

Abstract: Gastric cancer (GC) currently ranks as the fourth leading cause of cancer-related deaths worldwide. Genetic variations may influence GC by regulating genes. The aim of this study was to find pleiotropic genes associated with GC risk. Methods: Summary data-based Mendelian Randomization (SMR) is employed to identify genetic variations that are associated with the GC. The Gene interaction network of THBS3 was established through GeneMANIA, and the molecular pathogenesis was elucidated by function … Read More

Abstract: With the development of society, the incidence of mental illness is gradually increasing, and there are higher requirements for the quality of psychiatric diagnosis and treatment. At present, the lack of doctor-patient communication is in place is still the most important factor affecting the satisfaction of psychiatric diagnosis and treatment. An increasing number of studies focus on Solution-focused brief therapy in the diagnosis and treatment of mental illness to improve satisfaction and … Read More

Abstract: The incidence of depression has steadily increased in recent years, making it one of the most prevalent mental disorders. As the pursuit of new antidepressant drugs has attracted wide attention in the pharmaceutical community, the therapeutic effects of traditional Chinese medicine have also been extensively explored. Puerarin is commonly used as a vasodilator in the treatment of coronary heart disease including angina and myocardial ischemia, cerebral infarction, retinal vein occlusion, and … Read More

Abstract: Panax ginseng C.A. Meyer is a traditional and precious Chinese medicinal herb that is widely used in the fields of food, medicine, and cosmetics. This article provides a comprehensive overview of the research progress on Panax ginseng C.A. Meyer tissue culture from four aspects: the current utilization of Panax ginseng C.A. Meyer resources, Panax ginseng C.A. Meyer adventitious root culture, hairy root culture, and elicitor. The aim is to provide a reference for the rapid acquisition of … Read More

Abstract: This paper aims to explore the construction and application of an integrated diagnosis and treatment system for Mycoplasma pneumoniae pneumonia (MPP) in children within a specific region. MPP is a common respiratory infection among children, posing challenges in diagnosis and uncertainty in treatment outcomes. By integrating modern technologies and interdisciplinary medical resources, this paper proposes a comprehensive system aimed at enhancing diagnostic accuracy, personalized treatment … Read More

Abstract: This paper explores an intelligent response framework for battle injury treatment by revealing the bottlenecks and efficiency barriers in battlefield rescue response. It aims to achieve seamless coordination and maximum effectiveness of the treatment process in real combat scenarios. The concept of an automated battle injury survival chain is analyzed, and its components are demonstrated. The integration of sensing devices, communication networks, and big data analysis is discussed to support an … Read More

Abstract: Recently, the use of immune checkpoint inhibitors (ICIs) on triple negative breast cancer have been a hot research topic. immune checkpoints are vital as they prevent an immune response from being so strong that it kills healthy cells, which is unwanted. When T cell surface proteins bind to partner proteins (immune checkpoint proteins) on other cells, for instance tumor cells, immune checkpoints engage. When the checkpoint and immune checkpoint protein bind together, a signal is released to … Read More

Abstract: The purpose of this study is to explore the influence of ketogenic diet and intermittent fasting on the change of body fat rate, and to provide more scientific and effective methods for obese people to lose weight. Through randomized controlled trial design, 120 overweight or obese subjects were recruited and randomly divided into four groups for 12 weeks of dietary intervention. The control group kept their daily eating habits, while the ketogenic diet group adopted a diet scheme of high fat, … Read More

Abstract: In recent years, there have been reports suggesting that non-invasive brain stimulation (NIBS) can improve post-stroke complications. Non-invasive brain stimulation therapies include transcranial direct current stimulation (tDCS), transcranial magnetic stimulation (TMS), and intermittent theta burst stimulation (iTBS), among others. Clinically, a combination of one or more of these therapies is often used. However, it remains unclear which method is the most effective and safest for the recovery … Read More